Abstract
Signaling pathways involving nuclear receptors (NRs), their ligands and coregulators, regulate tissue-specific transcriptomes in diverse processes, including development, metabolism, reproduction, the immune response and neuronal function, as well as in their associated pathologies. The Nuclear Receptor Signaling Atlas (NURSA) is a Consortium focused around a Hub website (www.nursa.org) that annotates and integrates diverse 'omics datasets originating from the published literature and NURSA-funded Data Source Projects (NDSPs). These datasets are then exposed to the scientific community on an Open Access basis through user-friendly data browsing and search interfaces. Here, we describe the redesign of the Hub, version 3.0, to deploy "Web 2.0" technologies and add richer, more diverse content. The Molecule Pages, which aggregate information relevant to NR signaling pathways from myriad external databases, have been enhanced to include resources for basic scientists, such as post-translational modification sites and targeting miRNAs, and for clinicians, such as clinical trials. A portal to NURSA's Open Access, PubMed-indexed journal Nuclear Receptor Signaling has been added to facilitate manuscript submissions. Datasets and inform...Continue Reading
References
Jan 1, 1997·Nucleic Acids Research·E MartinezM Danielsen
Dec 1, 2001·Science·A ChawlaD J Mangelsdorf
Mar 23, 2002·Cell·Neil J McKenna, Bert W O'Malley
Dec 13, 2002·Nature·Alfred G GilmanUNKNOWN Participating investigators and scientists of the Alliance for Cellular Signaling
Dec 16, 2004·Environmental Health Perspectives·Jonathan G MoggsGeorge Orphanides
Apr 12, 2005·Journal of Molecular Endocrinology·J G MoggsG Orphanides
Sep 1, 2005·Science's STKE : Signal Transduction Knowledge Environment·Neil J McKenna, Bert W O'Malley
Nov 19, 2005·Chemosphere·Oliver J Hao
Jul 1, 2006·Endocrinology·Edmund C ChangBenita S Katzenellenbogen
Jun 27, 2008·BMC Medical Genomics·Scott A JelinskyHeather A Harris
Oct 8, 2008·Molecular and Cellular Biology·Poornima Bhat-NakshatriHarikrishna Nakshatri
Oct 31, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sergei Maslov, Sidney Redner
Mar 27, 2009·The Journal of Biological Chemistry·Stephanie L NottMesut Muyan
May 9, 2009·Molecular Endocrinology·Neil J McKennaBert W O'Malley
Jun 26, 2009·Biology of Reproduction·Elizabeth M SnyderMichael D Griswold
Sep 23, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Karen MathijsJoost H M van Delft
Feb 23, 2010·Toxicology·Jorge M NaciffGeorge P Daston
Jul 27, 2010·Advanced Drug Delivery Reviews·Ira G Schulman
Jul 30, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sylvia C HewittKenneth S Korach
Aug 24, 2010·Breast Cancer Research and Treatment·Robert S TolhurstLaki Buluwela
Oct 12, 2010·Advanced Drug Delivery Reviews·Elaine Y HsiaHong-Wu Chen
Nov 9, 2011·Nucleic Acids Research·Bas VrolingGert Vriend
Jul 13, 2012·Physiological Genomics·Scott A OchsnerNeil J McKenna
Nov 13, 2012·Molecular and Cellular Endocrinology·Marjo MalinenJorma J Palvimo
Nov 19, 2013·Acta Pharmacologica Sinica·Hu CaiJia-jun Zhao
Nov 28, 2013·Pharmacogenomics·Elena De MattiaGiuseppe Toffoli
May 6, 2014·Cell Metabolism·Laurent MouchiroudJohan Auwerx
Jul 11, 2014·Journal of the American Medical Informatics Association : JAMIA·Ronald MargolisEric D Green
Sep 30, 2014·Acta Pharmacologica Sinica·Chang-hong YiChun-fang Gao
Jan 24, 2015·Nuclear Receptor Signaling·Neil J McKennaBert W O'Malley
Citations
Oct 16, 2015·Nucleic Acids Research·Christopher SouthanUNKNOWN NC-IUPHAR
Jul 15, 2016·Journal of the American Medical Informatics Association : JAMIA·Yolanda F DarlingtonNeil J McKenna
Jul 14, 2016·Molecular Endocrinology·Scott A OchsnerNeil J McKenna
Dec 28, 2017·Nature Reviews. Genetics·Vineet K DhimanKevin P White
Jan 27, 2019·Molecular Neurobiology·Md JakariaDong-Kug Choi
Aug 6, 2020·International Journal of Molecular Sciences·Mari Ishigami-Yuasa, Hiroyuki Kagechika
Jul 22, 2018·Archives of Toxicology·Stephanie KimJennifer J Schlezinger
Feb 24, 2020·Cell Biology and Toxicology·Aziza Hussein Bakheit AdamIvonne M C M Rietjens
May 25, 2016·Molecular Pharmacology·Neil J McKenna
Apr 27, 2017·Science Signaling·Lauren B BecnelNeil J McKenna
Jun 23, 2021·Histochemistry and Cell Biology·Francesco De PascaliViktoria von Schönfeldt
Sep 25, 2021·Hepatology Communications·Emilian JungwirthMartin Wagner