Nuclear Receptor Signaling Atlas: Opening Access to the Biology of Nuclear Receptor Signaling Pathways

PloS One
Lauren B BecnelNeil J McKenna

Abstract

Signaling pathways involving nuclear receptors (NRs), their ligands and coregulators, regulate tissue-specific transcriptomes in diverse processes, including development, metabolism, reproduction, the immune response and neuronal function, as well as in their associated pathologies. The Nuclear Receptor Signaling Atlas (NURSA) is a Consortium focused around a Hub website (www.nursa.org) that annotates and integrates diverse 'omics datasets originating from the published literature and NURSA-funded Data Source Projects (NDSPs). These datasets are then exposed to the scientific community on an Open Access basis through user-friendly data browsing and search interfaces. Here, we describe the redesign of the Hub, version 3.0, to deploy "Web 2.0" technologies and add richer, more diverse content. The Molecule Pages, which aggregate information relevant to NR signaling pathways from myriad external databases, have been enhanced to include resources for basic scientists, such as post-translational modification sites and targeting miRNAs, and for clinicians, such as clinical trials. A portal to NURSA's Open Access, PubMed-indexed journal Nuclear Receptor Signaling has been added to facilitate manuscript submissions. Datasets and inform...Continue Reading

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Citations

Jul 15, 2016·Journal of the American Medical Informatics Association : JAMIA·Yolanda F DarlingtonNeil J McKenna
Dec 28, 2017·Nature Reviews. Genetics·Vineet K DhimanKevin P White
Aug 6, 2020·International Journal of Molecular Sciences·Mari Ishigami-Yuasa, Hiroyuki Kagechika
Jul 22, 2018·Archives of Toxicology·Stephanie KimJennifer J Schlezinger
May 25, 2016·Molecular Pharmacology·Neil J McKenna
Jun 23, 2021·Histochemistry and Cell Biology·Francesco De PascaliViktoria von Schönfeldt

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Methods Mentioned

BETA
dissections

Software Mentioned

Cytoscape JS
JBoss Linux
Firefox
JSMol viewer
JSMol
Internet Explorer
NURSA
Hibernate
Excel
dkNET

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