Nuclear receptors and chromatin: an inducible couple

Journal of Molecular Endocrinology
Raffaella Maria Gadaleta, Luca Magnani

Abstract

The nuclear receptor (NR) family comprises 48 transcription factors (TFs) with essential and diverse roles in development, metabolism and disease. Differently from other TFs, NRs engage with well-defined DNA-regulatory elements, mostly after ligand-induced structural changes. However, NR binding is not stochastic, and only a fraction of the cognate regulatory elements within the genome actively engage with NRs. In this review, we summarize recent advances in the understanding of the interactions between NRs and DNA. We discuss how chromatin accessibility and epigenetic modifications contribute to the recruitment and transactivation of NRs. Lastly, we present novel evidence of the interplay between non-coding RNA and NRs in the mediation of the assembly of the transcriptional machinery.

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Citations

Jul 27, 2014·Journal of Molecular Endocrinology·Silvia OttavianiLeandro Castellano
Jun 26, 2015·International Journal of Molecular Sciences·Rui ZhangGuoxun Chen
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Jun 2, 2021·Molecular and Cellular Endocrinology·Warren B Nothnick
Dec 1, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stefanie RuhsClaudia Grossmann

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