Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease

Mediators of Inflammation
Longgui NingGuoqiang Xu

Abstract

Nuclear receptors (NRs) are ligand-dependent transcription factors that regulate the transcription of target genes. Previous epidemiological and genetic studies have documented the association of NRs with the risk of inflammatory bowel disease (IBD). Although the mechanisms of action of NRs in IBD have not been fully established, accumulating evidence has demonstrated that NRs play complicated roles in regulating intestinal immunity, mucosal barriers, and intestinal flora. As one of the first-line medications for the treatment of IBD, 5-aminosalicylic acid (5-ASA) activates peroxisome proliferator-activated receptor gamma (PPARγ) to attenuate colitis. The protective roles of rifaximin and rifampicin partly depend on promoting pregnane X receptor (PXR) expression. The aims of this review are to discuss the roles of several important NRs, such as PPARγ, PXR, vitamin D receptor (VDR), farnesoid X receptor (FXR), and RAR-related orphan receptor gammat (RORγt), in the pathogenesis of IBD and management strategies based on targeting these receptors.

References

Oct 1, 1984·The Journal of Clinical Investigation·W F RigbyM W Fanger
Dec 15, 1995·Cell·D J MangelsdorfR M Evans
Oct 6, 1997·The Journal of Clinical Investigation·P PeraldiB M Spiegelman
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G Penna, L Adorini
Jun 28, 2001·Physiological Reviews·A Aranda, A Pascual
May 6, 2003·Gastroenterology·Laurent DubuquoyPierre Desreumaux
Sep 23, 2003·Molecular Endocrinology·Monica FroicuMargherita T Cantorna
Dec 20, 2003·The Journal of Biological Chemistry·Jane-L LewJisong Cui
Jul 6, 2004·Journal of Gastroenterology·Masahiro TajikaYasutoshi Muto
Oct 16, 2004·Reviews in Endocrine & Metabolic Disorders·Folkert KuipersBart Staels
Apr 13, 2005·The Journal of Experimental Medicine·Christel RousseauxPierre Desreumaux
Sep 24, 2005·Current Drug Targets. Immune, Endocrine and Metabolic Disorders·Giovanni RizzoStefano Fiorucci
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Wee-Chian LimYan Chun Li
Aug 12, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephen J KeelyAlan F Hofmann
Nov 11, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yatrik M ShahFrank J Gonzalez
Dec 16, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yatrik M ShahFrank J Gonzalez
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Agnes CosteKristina Schoonjans
Sep 11, 2007·Inflammatory Bowel Diseases·Alfonso MartínezElena Urcelay
Oct 27, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Juan KongYan Chun Li
Feb 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Alexandra AreVelmurugesan Arulampalam
Mar 8, 2008·Gastroenterology·James D LewisUNKNOWN Rosiglitazone for Ulcerative Colitis Study Group
Aug 13, 2008·Endocrine Reviews·Roger BouillonMarie Demay
Nov 21, 2008·Pharmacogenomics·Bin ZhangMatthew D Krasowski
Jan 10, 2009·Annual Review of Immunology·Thomas KornVijay K Kuchroo
Oct 28, 2009·Antimicrobial Agents and Chemotherapy·Eric L BrownHerbert L Dupont
Oct 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Piero VavassoriStefano Fiorucci
Feb 23, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandrine DubracMatthias Schmuth
May 25, 2010·Alimentary Pharmacology & Therapeutics·S P JørgensenJ F Dahlerup
Jun 12, 2010·BMC Gastroenterology·Amir J GuriJosep Bassaganya-Riera
Jun 23, 2010·The American Journal of Pathology·Shaoping WuJun Sun
Aug 26, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jie Gao, Wen Xie

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Citations

May 30, 2019·Scandinavian Journal of Immunology·Vinícius de Oliveira BoldriniGiovanna Rosa Degasperi
Mar 11, 2020·EMBO Molecular Medicine·Zdeněk DvořákSridhar Mani
Aug 6, 2020·International Journal of Molecular Sciences·Mahesh MohanKarol Sestak
Dec 16, 2020·International Journal of Molecular Sciences·Anyamanee ChaiprasongsukAndrzej T Slominski
Dec 10, 2020·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Jin-Nan WuJin-Liang Chen
Jun 1, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Wei WeiShukun Yao
Jul 31, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pedro M VelosoClarisse Nobre

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Methods Mentioned

BETA
IECs
fluorescence resonance
IEC

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