Nuclear receptors reverse McGarry's vicious cycle to insulin resistance.

Cell Metabolism
David D Moore

Abstract

Several pathways and pathologies have been suggested as connections between obesity and diabetes, including inflammation of adipose and other tissues, toxic lipids, endoplasmic reticulum stress, and fatty liver. One specific proposal is that insulin resistance induces a vicious cycle in which hyperinsulinemia increases hepatic lipogenesis and exacerbates fatty liver, in turn further increasing insulin resistance. Here I suggest that reversing this cycle via suppression of the lipogenic transcription factor SREBP-1c is a common thread that connects the antidiabetic effects of a surprising number of nuclear hormone receptors, including CAR, LRH-1, TRβ, ERα, and FXR/SHP.

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Citations

Mar 6, 2015·Biological Reviews of the Cambridge Philosophical Society·Francis W B Sanders, Julian L Griffin
Mar 27, 2013·Journal of Receptor and Signal Transduction Research·Harmit S Ranhotra
May 12, 2015·The Journal of Clinical Investigation·Xianghui FuWendong Huang
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Mar 14, 2017·The Journal of Clinical Investigation·Geoffrey A PreidisDavid D Moore
Jun 7, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Oludemilade AkinrotimiSayeepriyadarshini Anakk
Sep 12, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bingning DongDavid D Moore
Apr 27, 2019·Frontiers in Endocrinology·Hui XiaVincent Giguère
Dec 2, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Thomas W JacksonScott M Belcher
Mar 30, 2021·Frontiers in Pharmacology·Felix F LillichEwgenij Proschak

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