Nuclear roundness variance predicts prostate cancer progression, metastasis, and death: A prospective evaluation with up to 25 years of follow-up after radical prostatectomy

The Prostate
Robert W VeltriAlan W Partin

Abstract

Nuclear structure is often altered in cancer due to spatial rearrangements of chromatin organization via activation of oncogenes and other chromatin remodeling genes. Therefore, we evaluated the prognostic value of nuclear roundness variance (NRV) for prostate cancer (PCa) progression, metastasis and PCa-specific death free survivals in a cohort of 116 men after radical prostatectomy (RP). NRV was calculated for each case using the variance of the nuclear roundness from approximately 150 nuclei captured at a magnification of 2,440x for each case in 1992-1993. ${\rm Nuclear}\,{\rm roundness} = {{{\rm Radius}({\rm circumference})} \over {{\rm radius}({\rm area})}} = {R \over r} = {{P/2\pi } \over {\sqrt {A/\pi } }}$ NRV data were merged with clinical, pathologic, and follow-up data for all patients in 2009. Cox proportional hazards regression and Kaplan-Meier plots were employed to analyze the data. Median follow-up time after RP for all patients was 19 years (range: 1-25 years, mean: 17 years), with approximately 92% (107/116), 71% (82/116), and 47% (55/116) patients having >or=10, 15, and 20 years of follow-up, respectively. NRV was the most significant parameter for prediction of all three outcomes and its concordance-index ...Continue Reading

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Citations

Apr 17, 2012·Asian Journal of Andrology·Robert W VeltriSumit Isharwal
Jun 10, 2014·Pattern Recognition Letters·Hu HuangGustavo K Rohde
May 1, 2013·Archives of Pathology & Laboratory Medicine·Oleksandr N KryvenkoJonathan I Epstein
Mar 27, 2015·International Journal of Cancer. Journal International Du Cancer·Paola BarboroCecilia Balbi
Apr 14, 2012·IEEE Transactions on Medical Imaging·Sahirzeeshan Ali, Anant Madabhushi
Mar 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Richard K ValicentiLeonard G Gomella

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