PMID: 149910May 31, 1978

Nuclear suppressors of the [poky] cytoplasmic mutant in Neurospora crassa. III. Effects on other cytoplasmic mutants and on mitochondrial ribosome assembly in [poky

Molecular & General Genetics : MGG
R A Collins, H Bertrand

Abstract

We have previously isolated six non-allelic, nuclear mutations (sui loci) that partially suppress the growth, respiratory and cytochrome abnormalities of the extranuclear [poky] mutant. A comparison of the mitochondrial ribosome profiles of suppressed and unsuppressed [poky] strains revealed that five of the six suppressors alleviate at least partially the deficiency of mitochondrial small ribosomal subunits that is associated with the [poky] genotype. Six independently isolated Group 1 extranuclear mutants, namely [exn-1], [exn-2], [exn-4-a1, [stp-b1], [SG-1] and [SG-3-A1, which have growth and cytochrome phenotypes similar to [poky] also were found to be deficient in small subunits of mitochondrial ribosomes. Using cytochrome aa3 and b production as a criterion for mitochondrial protein synthesis, it could be shown that the nuclear su I suppressors of [poky] also suppress the other six Group I extranuclear mutants. However, differences in the efficiencies of suppression by suI suppressors suggest that at least some of Group I extrachromosomal mutants are not simply re-isolates of [poky], but represent distinct extranuclear mutations.

References

May 7, 1976·Molecular & General Genetics : MGG·A Coddington
Jun 1, 1976·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·J Kohout, H Bertrand
Mar 1, 1977·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·H Bertrand, J Kohout
Feb 16, 1972·Biochemical and Biophysical Research Communications·K P Schäfer, H Küntzel
Jul 1, 1972·The Journal of Cell Biology·P M Lizardi, D J Luck
Jan 1, 1972·Molecular & General Genetics : MGG·H Bertrand, T H Pittenger
Feb 5, 1973·Journal of Molecular Biology·Y Kuriyama, D J Luck
Jan 1, 1972·Annual Review of Genetics·J Davies, M Nomura
Jan 3, 1974·European Journal of Biochemistry·H Weiss, B Ziganke
Jan 1, 1974·Molecular & General Genetics : MGG·L A SaltzmanD Apirion
Dec 1, 1971·Journal of Bacteriology·A M Lambowitz, C W Slayman
Feb 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·M R Rifkin, D J Luck
Feb 1, 1956·Journal of General Microbiology·M B Mitchell, H K Mitchell
May 1, 1952·Proceedings of the National Academy of Sciences of the United States of America·M B Mitchell, H K Mitchell

Citations

Jan 1, 1979·Molecular & General Genetics : MGG·R A CollinsA M Lambowitz
May 23, 1979·Molecular & General Genetics : MGG·P Tudzynski, K Esser
Jun 1, 1991·Biochimie·M Kitakawa, K Isono
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R A Akins, A M Lambowitz
Jan 1, 1982·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·A RieckH Bertrand

Related Concepts

DNA, Mitochondrial
Mitochondria
Neurospora crassa
Ribosomes
Suppressor Mutation

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