Nuclear survivin in pN2 nonsmall cell lung cancer: prognostic and clinical implications

The European Respiratory Journal
Sherif MohamedI Yoshino

Abstract

Patients with N2 nonsmall cell lung cancer (N2-NSCLC) represent heterogeneous groups. Survivin is a member of the inhibitor of apoptosis family. If N2-NSCLC patients could be stratified, based on survivin expression and/or its relation to cell cycle proteins, into homogeneous subgroups, certain therapies could be selected for those patients. Survivin expression in 78 surgically resected primary pathological N2-NSCLC tumours was evaluated using immunohistochemistry. Relationships of survivin expression to overall survival, clinical features and expression of six cell cycle-related proteins (pRb, cyclin D1, p16(INK4A), p53, p21(Waf1) and Ki-67) were analysed. Nuclear survivin and the number of mediastinal lymph node (LN) stations were independent prognostic factors. The patient group with combined negative survivin/single mediastinal LN station were the most favourable prognostic group, and was related to the clinical nodal factor. Indeed, patients with negative survivin/low Ki-67 labelling indices had the best survival, especially in nonsquamous histopathology. The current authors conclude that nuclear survivin is strongly related to lymph node metastasis and proliferative potentials in pathological N2 nonsmall cell lung cancer ...Continue Reading

Citations

Apr 13, 2010·American Journal of Respiratory and Critical Care Medicine·Jean-Paul SculierAnne-Pascale Meert
Feb 18, 2014·International Journal of Molecular Sciences·Mahsa MobahatKarl Riabowol
May 31, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jinlong TongJianling Bai
Apr 17, 2013·Journal of the Egyptian National Cancer Institute·Amal FawzyMahmoud Eldeib
Sep 18, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yu-Lan XieJing Wang
Oct 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Elaheh Soleimanpour, Esmaeil Babaei
Feb 11, 2020·Frontiers in Oncology·Sebastian MarwitzTorsten Goldmann

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