Nucleic Acid Aptamers Targeting Epigenetic Regulators: An Innovative Therapeutic Option

Pharmaceuticals
Silvia CatuognoVittorio de Franciscis

Abstract

Epigenetic mechanisms include DNA methylation, posttranslational modifications of histones, chromatin remodeling factors, and post transcriptional gene regulation by noncoding RNAs. All together, these processes regulate gene expression by changing chromatin organization and DNA accessibility. Targeting enzymatic regulators responsible for DNA and chromatin modifications hold promise for modulating the transcriptional regulation of genes that are involved in cancer, as well as in chronic noncommunicable metabolic diseases like obesity, diabetes, and cardiovascular diseases. Increasingly studies are emerging, leading to the identification of specific and effective molecules targeting epigenetic pathways involved in disease onset. In this regard, RNA interference, which uses small RNAs to reduce gene expression and nucleic acid aptamers are arising as very promising candidates in therapeutic approach. Common to all these strategies is the imperative challenge of specificity. In this regard, nucleic acid aptamers have emerged as an attractive class of carrier molecules due to their ability to bind with high affinity to specific ligands, their high chemical flexibility as well as tissue penetration capability. In this review, we wi...Continue Reading

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Jan 6, 2019·Pharmaceuticals·Sarah Shigdar
May 1, 2020·European Heart Journal·Ulf LandmesserThomas F Lüscher
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Methods Mentioned

BETA
acetylation
SELEX
electrophoresis
PCR
CE-SELEX
Biosensors
biosensor
environmental stress

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