Jun 24, 2008

Nucleic acid encoding to program self-assembly in chemical biology

Chemical Society Reviews
Zbigniew L Pianowski, Nicolas Winssinger

Abstract

This tutorial review serves as an introduction to the use of oligonucleotides and in particular peptide nucleic acids (PNAs) to encode function beyond heredity. Applications in chemical biology are reviewed starting with the use of nucleic acid tags to program self-assembled microarrays of small and macromolecules, followed by the use of nucleic acid templated reactions for the purpose of DNA or RNA sensing and finally, the use of nucleic acid templates to display ligands.

  • References28
  • Citations24

References

  • References28
  • Citations24

Citations

Mentioned in this Paper

Peptide Nucleic Acids
Microarray Analysis
RNA Conformation
Combinatorial Chemistry Techniques
Heredity
Heredity Aspects
Macromolecule
Genetic Template
Oligonucleotides
Nucleic Acids

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