PMID: 5918575Sep 2, 1966

Nucleic acid guanine: reaction with the carcinogen N-acetoxy-2-acetylaminofluorene

E C MillerJ A Miller


Reaction of N-acetoxy-2-acetylaminofluorene with DNA or RNA at pH 7 causes marked increase in absorption at 280 to 320 millimicrons and marked decrease in guanine content. Reaction with guanosine-8-(14)C yields a radioactive fluorescent derivative. The data suggest that metabolic esters of N-hydroxy-2-acetylaminofluorene may be intermediates in the binding of this proximate carcinogen to nucleic acids in vivo.


Oct 1, 1977·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·H W Thielmann
Jun 18, 1968·Biochimica Et Biophysica Acta·K NakayaK Shibata
Oct 1, 1969·Chemico-biological Interactions·S M EpsteinE Farber
Jun 24, 1992·Journal of Immunological Methods·J L Guesdon
Nov 1, 1979·Mutation Research·D E LevinE Klekowski
Sep 1, 1981·Mutation Research·E C McCoyR Mermelstein
Oct 1, 1987·Journal of Hepatology·D LarzulJ L Guesdon
Jun 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·D GrunbergerI B Weinstein
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E Sage, M Leng
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A R Becker, L A Sternson
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P TchenM Leng
Jun 29, 2005·International Journal of Toxicology·F Peter Guengerich
Aug 26, 1985·Nucleic Acids Research·D G Sanford, T R Krugh
May 26, 1987·Nucleic Acids Research·S T NathL J Romano
Apr 1, 1979·Nucleic Acids Research·M Spodheim-MaurizotM Leng
Aug 1, 1978·Photochemistry and Photobiology·R W HartF B Daniel
Mar 1, 1983·Environmental Health Perspectives·J A Miller, E C Miller
Mar 15, 1972·International Journal of Cancer. Journal International Du Cancer·O G Fahmy, M J Fahmy
Jan 1, 1988·Critical Reviews in Biotechnology·R K JainG S Sayler
Jun 1, 2011·European Journal of Organic Chemistry·Heidi A Dahlmann, Shana J Sturla
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·D Grunberger, R M Santella
May 1, 1971·Biochemical Pharmacology·P BROOKES
Jul 13, 2013·Chemistry & Biodiversity·Renata Jurišić GrubešićSanda Vladimir-Knežević
Nov 10, 1977·Nature·M C PoirierS Blobstein
Aug 15, 1970·Klinische Wochenschrift·H G Neumann

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