PMID: 5918575Sep 2, 1966

Nucleic acid guanine: reaction with the carcinogen N-acetoxy-2-acetylaminofluorene

Science
E C MillerJ A Miller

Abstract

Reaction of N-acetoxy-2-acetylaminofluorene with DNA or RNA at pH 7 causes marked increase in absorption at 280 to 320 millimicrons and marked decrease in guanine content. Reaction with guanosine-8-(14)C yields a radioactive fluorescent derivative. The data suggest that metabolic esters of N-hydroxy-2-acetylaminofluorene may be intermediates in the binding of this proximate carcinogen to nucleic acids in vivo.

Citations

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Tumor Promoters
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