Nucleic acid methylation and orofacial morphogenesis

Birth Defects Research
Ratnam S SeelanRobert M Greene

Abstract

In this review, we highlight the current state of knowledge of the diverse roles nucleic acid methylation plays in the embryonic development of the orofacial region and how aberrant methylation may contribute to orofacial clefts. We also consider the role of methylation in the regulation of neural crest cell function as it pertains to orofacial ontogeny. Changes in DNA methylation, as a consequence of environmental effects, have been observed in the regulatory regions of several genes, potentially identifying new candidate genes for orofacial clefting and opening promising new avenues for further research. While the focus of this review is primarily on the nonsyndromic forms of orofacial clefting, syndromic forms are briefly discussed in the context of aberrant nucleic acid methylation.

References

Jun 1, 1991·Alcoholism, Clinical and Experimental Research·A J GarroC S Lieber
Jun 15, 1987·Biochemical and Biophysical Research Communications·D M WoodcockW P Diver
May 17, 1996·American Journal of Medical Genetics·P F GiampietroW T Brown
Jan 1, 1996·Human Molecular Genetics·M J Dixon
May 1, 1997·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·D F WyszynskiT H Beaty
Sep 18, 1997·Molecular Reproduction and Development·T L Wise, D D Pravatcheva
Jan 23, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M MelnickT Jaskoll
May 13, 1999·The New England Journal of Medicine·P F JacquesI H Rosenberg
Sep 25, 1999·Teratogenesis, Carcinogenesis, and Mutagenesis·S BranchB M Francis
Dec 28, 1999·Annual Review of Cell and Developmental Biology·C LaBonne, M Bronner-Fraser
Jan 11, 2000·Nucleic Acids Research·K D Pruitt, D R Maglott
Sep 28, 2002·Mechanisms of Development·Daisuke WatanabeShoji Tajima
Nov 8, 2002·Development·Laura S Gammill, Marianne Bronner-Fraser
May 6, 2003·The Journal of Nutrition·Carl L KeenMichael S Clegg
May 17, 2003·Birth Defects Research. Part A, Clinical and Molecular Teratology·Carmen Maestro de las CasasJulia Pérez-Miguelsanz
May 23, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Marit J BootAdriana C Gittenberger-de Groot
Oct 3, 2003·Nature Reviews. Neuroscience·Fabio Santagati, Filippo M Rijli
May 27, 2004·The Journal of Pain : Official Journal of the American Pain Society·Joseph L RileyGregg H Gilbert
Nov 24, 2004·American Journal of Medical Genetics. Part a·Joyce SoSusann Schweiger
Jan 13, 2005·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Joanna S ZeigerKung-Yee Liang
Jan 26, 2005·The Journal of Biological Chemistry·Tami L ThomaeChristopher A Bradfield
Apr 1, 2005·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Louisa S TangRichard H Finnell
Jun 3, 2005·Human Molecular Genetics·Bianca GonzalesBenigno C Valdez
Apr 14, 2006·Hormone Research·A L FowdenM Constancia
Aug 26, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Partha MukhopadhyayM Michele Pisano
Oct 17, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Heiko WurdakLukas Sommer
Jan 30, 2007·BMJ : British Medical Journal·Allen J WilcoxChristian A Drevon
Jul 20, 2007·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·Jens WeingärtnerPeter Proff
Sep 4, 2007·Brain Research Reviews·Nicole M Le DouarinSophie Creuzet
Sep 26, 2007·Journal of Medical Genetics·M M HagleitnerC M R Weemaes
Dec 25, 2007·Journal of Medical Genetics·S Abu-AmeroG E Moore
Jan 9, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Diana M Juriloff, Muriel J Harris
Mar 21, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Meghan S AdamsMarianne Bronner-Fraser
Jul 26, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Bart J B BliekAnnelies de Klein
Sep 16, 2008·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Motone KuriyamaChisato Mori

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Citations

Sep 15, 2020·Birth Defects Research·Michael A GarlandChengji J Zhou
Jun 1, 2021·Frontiers in Cell and Developmental Biology·Juan I YoungSusan H Blanton

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