Nucleic Acid-Sensing Pathways During SARS-CoV-2 Infection: Expectations versus Reality.

Journal of Inflammation Research
Bushra MdkhanaRabih Halwani


The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people and crippled economies worldwide. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for this pandemic has triggered avid research on its pathobiology to better understand the pathophysiology of COVID-19. In the absence of approved antiviral therapeutic strategies or vaccine platforms capable of effectively targeting this global threat, the hunt for effective therapeutics has led to many candidates being actively evaluated for their efficacy in controlling or preventing COVID-19. In this review, we gathered current evidence on the innate nucleic acid-sensing pathways expected to be elicited by SARS-CoV-2 and the immune evasion mechanisms they have developed to promote viral replication and infection. Within the nucleic acid-sensing pathways, SARS-CoV-2 infection and evasion mechanisms trigger the activation of NOD-signaling and NLRP3 pathways leading to the production of inflammatory cytokines, IL-1β and IL-6, while muting or blocking cGAS-STING and interferon type I and III pathways, resulting in decreased production of antiviral interferons and delayed innate response. Therefore, blocking the inflammatory arm and boostin...Continue Reading


Aug 2, 2003·Lancet·J CinatlH W Doerr
Dec 25, 2003·JAMA : the Journal of the American Medical Association·Mona R LoutfyEleanor N Fish
Feb 26, 2004·Nature Medicine·Bart L HaagmansAlbert D M E Osterhaus
Mar 20, 2004·The Journal of Infectious Diseases·Ute StröherHeinz Feldmann
May 12, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Martin SpiegelFriedemann Weber
Jun 18, 2004·Emerging Infectious Diseases·Emily L C TanLawrence W Stanton
Dec 17, 2004·Journal of Medical Virology·Kao-Jean HuangHuan-Yao Lei
Dec 21, 2004·Biochemical and Biophysical Research Communications·Birgit MorgensternJindrich Cinatl
Dec 22, 2004·Current Topics in Microbiology and Immunology·D A Brian, R S Baric
Aug 24, 2005·Virology Journal·Martin J VincentStuart T Nichol
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Aug 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Wataru KamitaniShinji Makino
Feb 15, 2008·Current Opinion in Immunology·Osamu Takeuchi, Shizuo Akira
Mar 28, 2008·Journal of Virology·Benjamin W NeumanPeter Kuhn
Dec 17, 2008·PLoS Pathogens·Timothy SheahanMark T Heise
Jan 6, 2009·Immunological Reviews·Mitsutoshi Yoneyama, Takashi Fujita
Aug 7, 2009·Journal of Virology·Andreas PichlmairCaetano Reis e Sousa
Oct 20, 2009·Nature Structural & Molecular Biology·Wataru KamitaniShinji Makino
Feb 26, 2010·Journal of Virology·Mark A ClementzSusan C Baker
Apr 2, 2010·Journal of Virology·Kristine M RoseSusan R Weiss
Dec 3, 2010·Nature·Rongbin ZhouJürg Tschopp
Dec 7, 2010·Journal of Structural Biology·Benjamin W NeumanMichael J Buchmeier
Aug 26, 2011·Current Opinion in Immunology·S Mehdi BelgnaouiJohn Hiscott
Sep 3, 2011·Immunological Reviews·Glen N Barber
Jan 20, 2012·Journal of Virology·Søren Jensen, Allan Randrup Thomsen

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