Nucleic Acid-Sensing Pathways During SARS-CoV-2 Infection: Expectations versus Reality.

Journal of Inflammation Research
Bushra MdkhanaRabih Halwani

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people and crippled economies worldwide. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for this pandemic has triggered avid research on its pathobiology to better understand the pathophysiology of COVID-19. In the absence of approved antiviral therapeutic strategies or vaccine platforms capable of effectively targeting this global threat, the hunt for effective therapeutics has led to many candidates being actively evaluated for their efficacy in controlling or preventing COVID-19. In this review, we gathered current evidence on the innate nucleic acid-sensing pathways expected to be elicited by SARS-CoV-2 and the immune evasion mechanisms they have developed to promote viral replication and infection. Within the nucleic acid-sensing pathways, SARS-CoV-2 infection and evasion mechanisms trigger the activation of NOD-signaling and NLRP3 pathways leading to the production of inflammatory cytokines, IL-1β and IL-6, while muting or blocking cGAS-STING and interferon type I and III pathways, resulting in decreased production of antiviral interferons and delayed innate response. Therefore, blocking the inflammatory arm and boostin...Continue Reading

References

Aug 2, 2003·Lancet·J CinatlH W Doerr
Dec 25, 2003·JAMA : the Journal of the American Medical Association·Mona R LoutfyEleanor N Fish
Feb 26, 2004·Nature Medicine·Bart L HaagmansAlbert D M E Osterhaus
Mar 20, 2004·The Journal of Infectious Diseases·Ute StröherHeinz Feldmann
May 12, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Martin SpiegelFriedemann Weber
Jun 18, 2004·Emerging Infectious Diseases·Emily L C TanLawrence W Stanton
Dec 17, 2004·Journal of Medical Virology·Kao-Jean HuangHuan-Yao Lei
Dec 21, 2004·Biochemical and Biophysical Research Communications·Birgit MorgensternJindrich Cinatl
Dec 22, 2004·Current Topics in Microbiology and Immunology·D A Brian, R S Baric
Aug 24, 2005·Virology Journal·Martin J VincentStuart T Nichol
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Aug 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Wataru KamitaniShinji Makino
Feb 15, 2008·Current Opinion in Immunology·Osamu Takeuchi, Shizuo Akira
Mar 28, 2008·Journal of Virology·Benjamin W NeumanPeter Kuhn
Dec 17, 2008·PLoS Pathogens·Timothy SheahanMark T Heise
Jan 6, 2009·Immunological Reviews·Mitsutoshi Yoneyama, Takashi Fujita
Aug 7, 2009·Journal of Virology·Andreas PichlmairCaetano Reis e Sousa
Oct 20, 2009·Nature Structural & Molecular Biology·Wataru KamitaniShinji Makino
Feb 26, 2010·Journal of Virology·Mark A ClementzSusan C Baker
Apr 2, 2010·Journal of Virology·Kristine M RoseSusan R Weiss
Dec 3, 2010·Nature·Rongbin ZhouJürg Tschopp
Dec 7, 2010·Journal of Structural Biology·Benjamin W NeumanMichael J Buchmeier
Aug 26, 2011·Current Opinion in Immunology·S Mehdi BelgnaouiJohn Hiscott
Sep 3, 2011·Immunological Reviews·Glen N Barber
Jan 20, 2012·Journal of Virology·Søren Jensen, Allan Randrup Thomsen

❮ Previous
Next ❯

Citations

Jul 20, 2021·Frontiers in Immunology·Rakhee K RamakrishnanImad M Tleyjeh

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA5
ubiquitination
nuclear
deubiquitinase
nuclear translocation

Clinical Trials Mentioned

NCT04326790
NCT04381936
NCT01327846
NCT02059291
NCT04339712
NCT04330638
NCT04315948
NCT04385095
NCT04276688
NCT04343768

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

© 2021 Meta ULC. All rights reserved