Nucleic Acid Sensors as Therapeutic Targets for Human Disease.

Immunity
Sarah M McWhirter, Caroline A Jefferies

Abstract

Innate immune sensors that detect nucleic acids are attractive targets for therapeutic intervention because of their diverse roles in many disease processes. In detecting RNA and DNA from either self or non-self, nucleic acid sensors mediate the pathogenesis of many autoimmune and inflammatory conditions. Despite promising pre-clinical data and investigational use in the clinic, relatively few drugs targeting nucleic acid sensors are approved for therapeutic use. Nevertheless, there is growing appreciation for the untapped potential of nucleic acid sensors as therapeutic targets, driven by the need for better therapies for cancer, infectious diseases, and autoimmune disorders. This review highlights the diverse mechanisms by which nucleic acid sensors are activated and exert their biological effects in the context of various disease settings. We discuss current therapeutic strategies utilizing agonists and antagonists targeting nucleic acid sensors to treat infectious disease, cancer, and autoimmune and inflammatory disorders.

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Citations

Jan 25, 2021·Journal of Experimental & Clinical Cancer Research : CR·Qiongyuan HuWenxian Guan
Dec 17, 2020·International Journal of Molecular Sciences·Ivy L DebreceniScott M Lieberman
Nov 7, 2020·EMBO Reports·Jonny Hertzog, Jan Rehwinkel
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Feb 4, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paola AllavenaFernando Torres Andón
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Sep 30, 2021·Molecular Medicine·Paola AllavenaCristina Belgiovine
Oct 29, 2021·Journal of Clinical and Experimental Hematopathology : JCEH·Norimitsu Kadowaki

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