Nucleic acid testing and molecular characterization of HIV infections

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Junpeng ZhaoLunan Wang

Abstract

Significant advances have been made in the molecular assays used for the detection of human immunodeficiency virus (HIV), which are crucial in preventing HIV transmission and monitoring disease progression. Molecular assays for HIV diagnosis have now reached a high degree of specificity, sensitivity and reproducibility, and have less operator involvement to minimize risk of contamination. Furthermore, analyses have been developed for the characterization of host gene polymorphisms and host responses to better identify and monitor HIV-1 infections in the clinic. Currently, molecular technologies including HIV quantitative and qualitative assays are mainly based on the polymerase chain reaction (PCR), transcription-mediated amplification (TMA), nucleic acid sequence-based amplification (NASBA), and branched chain (b) DNA methods and widely used for HIV detection and characterization, such as blood screening, point-of-care testing (POCT), pediatric diagnosis, acute HIV infection (AHI), HIV drug resistance testing, antiretroviral (AR) susceptibility testing, host genome polymorphism testing, and host response analysis. This review summarizes the development and the potential utility of molecular assays used to detect and characteri...Continue Reading

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Citations

Jul 1, 2021·Journal of the American College of Emergency Physicians Open·Kiran A FaryarUNKNOWN EMTIDE (Emergency Medicine Transmissible Infectious Diseases and Epidemics), Society for Academic Emergency Medicine

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Methods Mentioned

BETA
electron microscopy
PCR
Assay
nucleic acid extraction
nucleic acid
nucleic acid assays
RNA Assay
genotyping
PCRs
digital

Software Mentioned

Panther
QuantStudio 3D Digital PCR System
Trugene
APTIMA
Ultrio
Liat HIV Quant
EOSCAPE
Alere
POCT
QuantStudio

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