Nucleic Acids-based Nanotherapeutics Crossing the Blood Brain Barrier

Current Gene Therapy
Noha Nafee, Noha Gouda

Abstract

The restless endeavors revealing the molecular pathways underlying many neurodegenerative diseases and brain tumors have paved the way for the introduction of the selective exogenous gene-based therapeutics. The implicated active biomolecules encompass mainly negatively-charged nucleic acids ranging from DNA, mRNA, non-coding RNAs (small-interfering RNA, siRNA, and microRNA, miRNA), to antisense oligonucleotides. They selectively interfere with the genes translational and/or transcriptional processes. Although many reviews previously addressed brain targeting, a thorough correlation between the molecular properties of these biomacromolecules, the nature of blood brain barrier (BBB) in the accompanying pathological condition, the intracellular targets, as well as the design of the delivery system which will transport the bioactive cargo to the target cells attempting efficient delivery to the active sites in the brain will be appraised. In this review, we will further discuss the tremendous advances in non-viral gene delivery nanosystems currently investigated (starting from self-assembled nanoplexes using cationic polymers or lipids and going through liposomes, aptamers, polymersomes, exosomes, dendrimers and nanoparticles). Un...Continue Reading

Citations

Oct 4, 2018·Current Gene Therapy·Cen YanYing-Mei Feng
Dec 5, 2019·Cancer Metastasis Reviews·Julia Alejandra PezukMaría Sol Brassesco
Sep 27, 2018·International Journal of Molecular Sciences·Martina Da RosIacopo Sardi
Mar 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Catherine M GorickRichard J Price
Jul 28, 2020·Advanced Drug Delivery Reviews·Fangli MoWeihong Tan

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