Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge

PLoS Neglected Tropical Diseases
Marko ZivcecHeinz Feldmann

Abstract

Crimean-Congo hemorrhagic fever (CCHF) is an acute, often fatal viral disease characterized by rapid onset of febrile symptoms followed by hemorrhagic manifestations. The etiologic agent, CCHF orthonairovirus (CCHFV), can infect several mammals in nature but only seems to cause clinical disease in humans. Over the past two decades there has been an increase in total number of CCHF case reports, including imported CCHF patients, and an expansion of CCHF endemic areas. Despite its increased public health burden there are currently no licensed vaccines or treatments to prevent CCHF. We here report the development and assessment of the protective efficacy of an adenovirus (Ad)-based vaccine expressing the nucleocapsid protein (N) of CCHFV (Ad-N) in a lethal immunocompromised mouse model of CCHF. The results show that Ad-N can protect mice from CCHF mortality and that this platform should be considered for future CCHFV vaccine strategies.

References

May 1, 1989·The American Journal of Tropical Medicine and Hygiene·A J ShepherdR Swanepoel
Mar 30, 2004·Journal of Virology·Ida AnderssonAli Mirazimi
Dec 24, 2005·Journal of Medical Virology·Ida AnderssonAli Mirazimi
Mar 24, 2006·The Lancet Infectious Diseases·Onder Ergönül
Apr 25, 2006·Virus Research·M SimonA Mirazimi
Jan 20, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Scott E HensleyHildegund C J Ertl
Jun 8, 2007·BMC Infectious Diseases·Kenan MidilliFrans Jongejan
Sep 1, 2007·Current Opinion in Infectious Diseases·Regina VorouHelen C Maltezou
Nov 28, 2009·Virus Research·Aykut OzdarendeliAhmet Kalkan
Feb 19, 2010·The Journal of General Virology·Sándor BereczkyAli Mirazimi
Jul 14, 2012·PloS One·Kerstin WernikeMichael Eschbaumer
Aug 12, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·S LumleyR Hewson
Dec 3, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Anna PapaHeinz Feldmann
Dec 23, 2014·Emerging Infectious Diseases·Nicholas G CongerMark G Kortepeter
Apr 26, 2016·Viruses·Marko ZivcecÉric Bergeron
May 10, 2017·The Journal of Infectious Diseases·Jessica R SpenglerChristina F Spiropoulou
May 19, 2017·Emerging Infectious Diseases·Pragya D YadavDevendra T Mourya
Sep 19, 2017·PLoS Neglected Tropical Diseases·Aura R GarrisonConnie S Schmaljohn

❮ Previous
Next ❯

Citations

Nov 13, 2018·F1000Research·David W Hawman, Heinz Feldmann
Jul 3, 2019·Viruses·Aura R GarrisonJoseph W Golden
Jul 12, 2019·Journal of Virology·David W HawmanHeinz Feldmann
Sep 19, 2019·Vaccines·Touraj Aligholipour FarzaniAykut Ozkul
May 29, 2020·BioResearch Open Access·Thomas Tipih, Felicity Jane Burt
Jan 11, 2019·Viruses·Alejandro Marín-LopezJavier Ortego
Sep 7, 2020·Travel Medicine and Infectious Disease·Enrica SerretielloMassimiliano Galdiero
Jun 18, 2021·Scientific Reports·Tahmineh JalaliSeyed Latif Mousavi Gargari
Jul 17, 2021·PLoS Pathogens·De-Sheng KerAlfred A Antson
Dec 2, 2021·PLoS Neglected Tropical Diseases·Elif KaraaslanMehmet Ziya Doymaz

❮ Previous
Next ❯

Methods Mentioned

BETA
gene knockouts
ELISA

Software Mentioned

GraphPad
GraphPad Prism

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Argentine Hemorrhagic Fever

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by junín virus (JUNV), a member of the arenaviridae family. Discover the latest research on AHF here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.