Nucleocytoplasmic trafficking is essential for BAK1- and BKK1-mediated cell-death control

The Plant Journal : for Cell and Molecular Biology
Junbo DuJia Li

Abstract

BRI1-ASSOCIATED KINASE 1 (BAK1) was initially identified as a co-receptor of the brassinosteroid (BR) receptor BRI1. Genetic analyses also revealed that BAK1 and its closest homolog BAK1-LIKE 1 (BKK1) regulate a BR-independent cell-death control pathway. The double null mutant bak1 bkk1 displays a salicylic acid- and light-dependent cell-death phenotype even without pathogen invasion. Molecular mechanisms of the spontaneous cell death mediated by BAK1 and BKK1 remain unknown. Here we report our identification of a suppressor of bak1 bkk1 (sbb1-1). Genetic analyses indicated that cell-death symptoms in a weak double mutant, bak1-3 bkk1-1, were completely suppressed by the loss-of-function mutation in SBB1, which encodes a nucleoporin (NUP) 85-like protein. Genetic analyses also demonstrated that individually knocking out three other nucleoporin genes from the SBB1-located sub-complex was also able to rescue the cell-death phenotype of bak1-3 bkk1-1. In addition, a DEAD-box RNA helicase, DRH1, was identified in the same protein complex as SBB1 via a proteomic approach. The drh1 mutation also rescues the cell-death symptoms of bak1-3 bkk1-1. Further analyses indicated that export of poly(A)(+) RNA was greatly blocked in the nup an...Continue Reading

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Citations

Sep 24, 2016·Trends in Plant Science·Xiyu MaLibo Shan
Sep 14, 2017·International Journal of Molecular Sciences·Shuhua HuangXiaofeng Wang
Dec 13, 2017·PLoS Genetics·Yingfang ZhuJian-Kang Zhu
May 28, 2019·Journal of Integrative Plant Biology·Yaqiong LiuSuiwen Hou
May 29, 2016·The Journal of Biological Chemistry·Meral Tunc-OzdemirAlan M Jones
Jul 27, 2018·Planta·Joydeep ChakrabortySampa Das
Jan 24, 2019·Frontiers in Plant Science·Xiquan GaoBaomin Feng
Apr 10, 2020·International Journal of Molecular Sciences·Benedict C OfforLizelle A Piater
Feb 26, 2020·International Journal of Molecular Sciences·Shan ZhangXiaofeng Wang
Dec 3, 2016·Frontiers in Plant Science·Rowan van WerschYuelin Zhang
Oct 14, 2020·Molecular Plant-microbe Interactions : MPMI·You Lu, Kenichi Tsuda
May 2, 2017·Current Opinion in Plant Biology·Shigetaka YasudaYusuke Saijo
Aug 17, 2021·Frontiers in Plant Science·Daniel LüdkeMarcel Wiermer

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