Nucleocytoplasmic transport: factors and mechanisms

FEBS Letters
G Simos, E C Hurt

Abstract

In the past two years, our knowledge concerning the mechanisms of nucleocytoplasmic transport through the nuclear pore complex (NPC) has considerably expanded. The application of in vitro systems that reconstitute nuclear protein import has allowed the identification of cytosolic factors that are required for the import process. Microinjection into Xenopus oocytes and yeast genetic systems have provided interesting candidates for RNA export mediators. Functional and structural analysis of nucleoporins has demonstrated the involvement of NPC components in the transport process. Finally, new concepts have emerged such as the integration of the mechanisms of the nuclear protein import and RNA export reactions and the assembly of the transport machinery at specialised domains of the NPC.

References

Jun 1, 1978·Cell·A K Hopper, F Banks
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·Z GuD S Goldfarb
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T KadowakiA M Tartakoff
Aug 1, 1992·Seminars in Cell Biology·E Izaurralde, I W Mattaj
Aug 1, 1992·Seminars in Cell Biology·M L Zapp
Nov 1, 1992·The Journal of Cell Biology·S R WenteG Blobel
Jul 10, 1992·Cell·U T Meier, G Blobel
Jul 1, 1991·The Journal of Cell Biology·D R FinlayD J Forbes
Jul 1, 1990·Molecular and Cellular Biology·H E Neuman de Vegvar, J E Dahlberg
Feb 1, 1987·The Journal of Cell Biology·D R FinlayD J Forbes
Mar 1, 1994·The Journal of Cell Biology·A JarmolowskiI W Mattaj
May 1, 1994·Trends in Biochemical Sciences·M S Moore, G Blobel
Aug 1, 1994·The Journal of Cell Biology·S HuangD L Spector
Nov 1, 1994·Journal of Structural Biology·N Panté, U Aebi
Apr 21, 1995·Cell·E Izaurralde, I W Mattaj
Apr 1, 1995·Current Opinion in Genetics & Development·M L Zapp
Apr 1, 1995·Molecular Biology of the Cell·R SchneiterA M Tartakoff

❮ Previous
Next ❯

Citations

Nov 19, 1997·Progress in Neurobiology·A F Rocha
Oct 25, 2000·Brain Research Bulletin·K Ohtsuka, T Suzuki
Apr 1, 1996·Current Opinion in Structural Biology·M Stewart, W D Clarkson
Apr 1, 1996·Critical Reviews in Biochemistry and Molecular Biology·N Panté, U Aebi
Nov 26, 1997·Journal of Virology·G NeumannY Kawaoka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Genetics & Development
M L Zapp
Annual Review of Biochemistry
L I Davis
Proceedings of the National Academy of Sciences of the United States of America
O KeminerR Peters
Traffic
Melanie L YarbroughBeatriz M A Fontoura
© 2021 Meta ULC. All rights reserved