Nucleocytoplasmic transport

Science
D Görlich, I W Mattaj

Abstract

Active transport of proteins and RNAs between the nucleus and cytoplasm is a major process in eukaryotic cells. Recently, factors that recognize transport substrates and mediate nuclear import or export have been characterized, revealing interactions that target substrates to the nuclear pore complexes, through which translocation occurs. Translocation requires energy, and for the import process this energy is at least partly consumed by the action of the small guanosine triphosphatase Ran. In the first half of the review, some of the well-established general background information on nucleocytoplasmic transport is discussed. The second half describes recent information on the mechanistic details of nuclear import and export as well as major unresolved issues such as how directionality is conferred on either import or export. The whole review is slanted toward discussion of metazoan cells.

Associated Clinical Trials

References

Feb 20, 1992·Nature·S Piñol-Roma, G Dreyfuss
Aug 1, 1992·Seminars in Cell Biology·E Izaurralde, I W Mattaj
Dec 1, 1991·Trends in Biochemical Sciences·C Dingwall, R A Laskey
Jan 1, 1991·The Journal of Cell Biology·N Michaud, D S Goldfarb
Sep 1, 1991·Trends in Biochemical Sciences·B R Cullen, M H Malim
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·F R Bischoff, H Ponstingl
Aug 14, 1986·Nature·D S GoldfarbR D Kornberg
Dec 1, 1984·The Journal of Cell Biology·C M FeldherrN Schultz
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M Zasloff
Mar 1, 1994·The Journal of Cell Biology·A JarmolowskiI W Mattaj
Apr 21, 1995·Cell·E Izaurralde, I W Mattaj
Oct 1, 1995·Nature Genetics·M A Andrade, P Bork
Jan 1, 1995·Annual Review of Biochemistry·L I Davis
Jul 13, 1995·Nature·N YokoyamaU Aebi
Jul 1, 1995·The Journal of Cell Biology·N C ChiS A Adam
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·C DingwallB Séraphin
Aug 24, 1995·Nature·E IzaurraldeI W Mattaj

❮ Previous
Next ❯

Citations

May 16, 1996·Nature·S E Egan, R R McInnes
Jun 24, 1996·FEBS Letters·G Schlenstedt
Dec 20, 1996·The Journal of Biological Chemistry·K M LounsburyI G Macara
Feb 21, 1997·The Journal of Biological Chemistry·G RussoC Pietropaolo
Jan 1, 1997·Annual Review of Neuroscience·S NakielnyG Dreyfuss
May 30, 1997·The Journal of Biological Chemistry·T KamitaniE T Yeh
Aug 22, 1997·The Journal of Biological Chemistry·B M PaschalL Gerace
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·T D Sweitzer, J A Hanover
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·H SaitohM Dasso
Jan 15, 1998·European Journal of Biochemistry·M Vihinen-RantaM Vuento
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·O SchatzJ Hauber
Jan 1, 1997·Annual Review of Cell and Developmental Biology·T M Gant, K L Wilson
Jul 3, 1998·Clinical Genetics·A S HackamM R Hayden
Jun 25, 1998·Molecular and Cellular Biology·M C SiomiG Dreyfuss
Jul 21, 1998·The Journal of Biological Chemistry·P BouvetF Amalric
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·L De AngelisG Cossu
Dec 16, 1998·Nature Biotechnology·N UekiM Muramatsu
Oct 17, 1998·Molecular and Cellular Biology·J SolsbacherG Schlenstedt
Jan 19, 1999·Annual Review of Microbiology·V W Pollard, M H Malim
Oct 6, 1998·Annual Review of Biochemistry·I W Mattaj, L Englmeier
Jan 26, 1999·Critical Reviews in Biochemistry and Molecular Biology·R Tuteja, N Tuteja
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·D C LoveJ A Hanover
Jan 9, 1999·The Plant Journal : for Cell and Molecular Biology·C WimmerC Gietl
Feb 13, 1999·The Journal of Biological Chemistry·J HerringtonC Carter-Su
Jul 28, 1999·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·M WatanabeE Nishida

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
Y Yoneda
Current Opinion in Cell Biology
Elena Conti, E Izaurralde
Microbiology and Molecular Biology Reviews : MMBR
Anita H Corbett, P A Silver
© 2021 Meta ULC. All rights reserved