Nucleolar and spindle-associated protein 1 accelerates cellular proliferation and invasion in nasopharyngeal carcinoma by potentiating Wnt/β-catenin signaling via modulation of GSK-3β.

Journal of Bioenergetics and Biomembranes
Ligang ZhangXin Fan

Abstract

Nucleolar and spindle-associated protein 1 (NUSAP1) is a pivotal tumor-related protein that has been implicated in the progression of broad spectrum of tumors. However, no detailed study of the role of NUSAP1 in nasopharyngeal carcinoma (NPC) has been reported. The aim of this work is to enhance our understanding of NUSAP1 in the progression of NPC. By analyzing data available within the Oncomine database, we found that NUSAP1 expression was elevated in NPC relative to normal tissues. Further, we showed that NUSAP1 expression in clinical specimens of NPC and several NPC cell lines was elevated. Down-regulation of NUSAP1 by gene silencing markedly depleted the capacity of NPC cells to proliferate and invade. Contrastingly, overexpression of NUSAP1 potentiated the proliferative and invasive abilities of NPC cells. Further mechanistic research revealed that NUSAP1 knockdown decreased levels of Wnt/β-catenin signaling in NPC cells via a mechanism associated with downregulation of glycogen synthase kinase-3β (GSK-3β) phosphorylation. However, suppression of GSK-3β markedly abolished the inhibitory effect of NUSAP1 knockdown on Wnt/β-catenin signaling. Further, inhibition of Wnt/β-catenin signaling partially reversed NUSAP1-mediated ...Continue Reading

References

Jul 1, 1997·The EMBO Journal·H AberleR Kemler
Sep 10, 2003·The Journal of Cell Biology·Tim RaemaekersGeert Carmeliet
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Catriona Y Logan, Roel Nusse
May 1, 2008·Head & Neck·Josephine ChouDavid M Jablons
Jan 5, 2011·Protein & Cell·Jing NieHuizhe Huang
Jun 13, 2012·Seminars in Radiation Oncology·Anne W M LeeWai T Ng
Nov 22, 2012·Cold Spring Harbor Perspectives in Biology·Jennifer L Stamos, William I Weis
Jan 15, 2015·The Prostate·Catherine A GordonJames D Brooks
Sep 1, 2015·Lancet·Melvin L K ChuaAnthony T C Chan
Apr 14, 2017·Oncotarget·Catherine A GordonJames D Brooks
Sep 14, 2017·Journal of Experimental & Clinical Cancer Research : CR·Xianqiu WuWei Zhang
Sep 14, 2017·The Journal of Biological Chemistry·Christine A MillsMichael J Emanuele
Jun 2, 2018·Pathology, Research and Practice·Zhaoxiu LiuZhaolian Bian
Jul 12, 2018·Journal of Neuro-oncology·Zhiyuan QianJun Dong
Jan 27, 2019·Journal of Experimental & Clinical Cancer Research : CR·Han LiYanna Zhang
Apr 23, 2020·Signal Transduction and Targeted Therapy·Yuzu ZhaoHongjuan Cui
May 6, 2020·Cells·Przemysław DudaJames A McCubrey

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