Nucleolar caspase-2: Protecting us from DNA damage

The Journal of Cell Biology
Kenneth J O'Byrne, Derek J Richard

Abstract

Caspase-2 triggers apoptosis, but how it is activated by different stimuli is unclear. In this issue, Ando et al. (2017.J. Cell Biol.https://doi.org/10.1083/jcb.201608095) delineate two pathways of caspase-2 activation and show that, in response to DNA damage, caspase-2 forms a complex with the PIDDosome and NPM1 within the nucleolus.

References

Sep 29, 2009·Molecular Cell·Lisa Bouchier-HayesDouglas R Green
Apr 14, 2012·Cell Death and Differentiation·L DorstynS Kumar
Jul 3, 2013·Cell Death and Differentiation·J PucciniS Kumar
Aug 25, 2016·BMC Molecular Biology·Joseph K BoxDerek J Richard
Apr 23, 2017·The Journal of Cell Biology·Kiyohiro AndoLisa Bouchier-Hayes

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Methods Mentioned

BETA
pulldown

Software Mentioned

PIDDosome

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