PMID: 1591687Jun 15, 1992

Nucleolar organizer region enumeration in keratoacanthomas and squamous cell carcinomas of the skin

Cancer
J KanitakisJ Thivolet

Abstract

Keratoacanthomas (KA) and squamous cell carcinomas (SSC) are epithelial skin tumors exhibiting distinctive clinical and histologic features. However, the differential diagnosis between them in individual cases may be difficult or even impossible. In this article the authors examine the possibility that enumeration of associated proteins of nucleolar organizer regions (AgNOR) could be of help in differentiating KA from SCC. AgNOR counting, performed on unequivocal cases of SCC (n = 20) and KA (n = 16) showed statistically significant higher AgNOR counts in SCC (6.29 +/- 0.91) compared with KA (3.80 +/- 1.62). This result speaks in favor of the different biologic nature of SCC and KA; however, due to significant overlap between the two groups, AgNOR enumeration alone is not sufficiently discriminating so as to be used diagnostically in cases with borderline histologic features.

References

Aug 20, 1979·Life Sciences·M A LischweH Busch
Jan 1, 1979·The British Journal of Dermatology·A Rook, I Whimster
Dec 1, 1977·Journal of Cutaneous Pathology·I P JaneckaB Cosman
Apr 1, 1990·Journal of Cutaneous Pathology·Y MerotE Frenk
Feb 1, 1990·The American Journal of Dermatopathology·G Kannon, H K Park
Apr 1, 1990·Journal of Cutaneous Pathology·A C MarkeyD M MacDonald
Feb 1, 1990·American Journal of Clinical Pathology·M B RandallR W Prichard
Mar 1, 1988·The Journal of Pathology·M J Egan, J Crocker
Oct 1, 1989·American Journal of Clinical Pathology·P A DervanD N Carney
Jul 1, 1988·Histopathology·M E FallowfieldM G Cook
Jun 1, 1988·The Journal of Pathology·J C Underwood, D D Giri
Oct 1, 1987·The British Journal of Dermatology·R M GrahamJ R Nash
Sep 1, 1988·Archives of Dermatology·P H Cooper, J T Wolfe
Mar 8, 1969·Lancet·I T Jackson
May 1, 1984·The Journal of Investigative Dermatology·G F MurphyG S Pinkus
Oct 1, 1980·Journal of Cutaneous Pathology·W H Kern, M K McCray

Citations

Dec 3, 1992·The New England Journal of Medicine·D S Preston, R S Stern
Jan 22, 2002·The American Journal of Dermatopathology·G TuccariD Batolo
Jan 1, 1996·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A E SchwintM E Itoiz
Dec 2, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·V MisraA K Gupta
Oct 24, 2007·Pathology, Research and Practice·Kiriaki AroniEleftherios Ioannidis
Aug 4, 2007·Pathology, Research and Practice·Kiriaki AroniEfstratios Patsouris
Jun 29, 2012·Oncology Letters·Ivonne Andrea Muñoz RuzCésar Andrés Rivera Martínez

Related Concepts

Squamous Cell Carcinoma
Differential Diagnosis
Keratoacanthoma
Nucleolus Organizer Region
Dermatologic Disorders
Malignant Neoplasm of Skin
Silver Stain Method

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Dermatology : International Journal for Clinical and Investigative Dermatology
A Rebora
Archives of Dermatological Research
J M BonnetblancF Bonnetblanc
The Journal of Dermatologic Surgery and Oncology
J Bryant
A.M.A. Archives of Dermatology and Syphilology
T B MAXWELL, J H LAMB
© 2021 Meta ULC. All rights reserved