PMID: 15381904Sep 24, 2004Paper

Nucleolar organizer regions as a prognostic indicator in epithelial cancers of the ovary

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Shatrughan Prasad SahSiddhartha Datta Gupta

Abstract

Recent studies have shown that quantification of silver-stained nucleolar organizer region associated proteins (AgNORs) is correlated with ploidy and proliferative activity in several neoplasms. The prognostic value of this marker, however, has not been well defined in epithelial ovarian carcinomas (EOCs). We studied 84 cases of EOCs in an attempt to assess the potential prognostic significance of AgNORs and to compare the results with other prognostic factors in EOCs. Clinical, operative and treatment details, and follow-up data were recorded for each case. In univariate analysis, a highly significant correlation of AgNOR count with clinical stage (p < 0.01), histologic grade (p < 0.05), response to chemotherapy (p < 0.05), and biologic behavior (p < 0.01) was found. High AgNOR counts were observed in late stage (III and IV) tumors, grade 3 carcinomas, tumors in patients with partial response to chemotherapy, progressive disease, recurrence, or death from tumor. In multivariate analysis, AgNOR count at cut off 3.5 was found to be the third prognostic variable after response to therapy and stage. These observations suggest that AgNOR count holds promise for prediction of tumor aggressiveness in EOCs. However, its role as an ind...Continue Reading

References

Jan 1, 1992·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A KhattechC Lhommé
Apr 1, 1990·Histopathology·F A MauriG Perrone
Nov 1, 1991·Histopathology·A BagniG P Trentini
Feb 1, 1990·Cancer·H E Averette, D M Donato
Feb 1, 1987·The Journal of Pathology·J Crocker, P Nar
Dec 1, 1989·Journal of Clinical Pathology·A P GriffithsM Wells
Jun 1, 1989·British Journal of Obstetrics and Gynaecology·W S Wong, M H Tattersall
Jun 1, 1988·The Journal of Pathology·J C Underwood, D D Giri
Jan 1, 1981·Cancer·A B MillerA Winkler
Oct 1, 1993·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A P GriffithsP Quirke
Jul 1, 1993·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·M CriscuoloC De Gaetani
Feb 1, 1993·The Journal of Pathology·S Toikkanen, H Joensuu
Jan 1, 1996·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A R MarcelliK R Mittal
Apr 1, 1997·American Journal of Clinical Pathology·M GhazizadehK Aihara
Jan 11, 2001·Gynecologic and Obstetric Investigation·S ZergeroğluO Gökmen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.