PMID: 1201687Nov 24, 1975Paper

Nucleolar RNA synthesis of meiotic prophase spermatocytes in the human testis

Chromosoma
L L Tres

Abstract

Human meiotic prophase spermatocyte nuclei were studied by electron microscope autoradiography after a 3 hours 3H-uridine labeling pulse, followed by postincubation in non-radioactive medium. In autosomes, 3H-uridine nucleolar labeling reaches a peak during early-middle zygotene prior to the peak labeling of chromosmal RNA species at middle pachytene. Transcription activities of sex chromosomes are inconspicuous when compared with that of autosomes. An increasing condensation of nucleolar-associated chromatin in acrocentric bivalents contributes to the formation of basal knobs in human pachytene spermatocytes. Upon completion of knob formation, nucleolar components segregate and the uptake of 3H-uridine decreases. These findings suggest that the template capability of ribosomal DNA cistrons, located next to the basal knob region, is largely associated with a dispersed state of chromatin whereas increased chromatin condensation is correlated with a restriction of ribosomal RNA transcription.

References

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Apr 2, 2005·Science·R McNeill Alexander

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Citations

Sep 1, 1990·The American Journal of Anatomy·M C Schultz, C P Leblond
Aug 31, 1977·Human Genetics·W EngelM Schmid
May 16, 1978·Chromosoma·A J Solari, O Vilar
Aug 1, 1996·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·C SchöferF Wachtler
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A StahlM Guichaoua
Jul 1, 1977·The Journal of Cell Biology·C F Millette, A R Bellvé
Feb 23, 2012·PloS One·Marieke de VriesPeter de Boer
Oct 15, 1986·Experientia·A C Chandley
Dec 1, 1982·Experimental Cell Research·R M DePhilipA L Kierszenbaum
Aug 1, 1979·Experimental and Molecular Pathology·K O Söderström

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