Nucleolus-Targeted Red Emissive Carbon Dots with Polarity-Sensitive and Excitation-Independent Fluorescence Emission: High-Resolution Cell Imaging and in Vivo Tracking

ACS Applied Materials & Interfaces
Xian-Wu HuaFu-Gen Wu

Abstract

Red-emitting carbon dots (CDs) have attracted tremendous attention with wide applications in areas including imaging, sensing, drug delivery, and cancer therapy. However, it is still highly challenging for red-emitting CDs to simultaneously achieve high quantum yield (QY), nucleus targeting, and super-resolution fluorescence imaging (especially the stimulated emission depletion (STED) imaging). Here, it is found that the addition of varied metal ions during the hydrothermal treatment of p-phenylenediamine (pPDA) leads to the formation of red emissive CDs with QYs varying from 1.6% to 45.6%. Strikingly, although metal ions play a crucial role in the synthesis of CDs with varied QYs, they are absent in the formed CDs; that is, the obtained CDs are metal-free and the metal ions play a role similar to a "catalyst" during the CD formation. Besides, using pPDA and nickel ions (Ni2+) as raw materials, we prepare Ni-pPCDs which have the highest QY and exhibit various excellent fluorescence properties including excitation-independent emission (at ~605 nm), good photostability, polarity sensitivity, and ribonucleic acid responsiveness. In vitro and in vivo experiments demonstrate that Ni-pPCDs are highly biocompatible and can realize rea...Continue Reading

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Citations

Oct 13, 2020·Luminescence : the Journal of Biological and Chemical Luminescence·Qian LiuChangli Lü
Jan 22, 2021·Colloids and Surfaces. B, Biointerfaces·Anjana SharmaDeepa Ghosh
Apr 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sayed Mir SayedXiaolin Lu
May 8, 2021·Frontiers in Chemistry·Yanfeng LiuJunle Qu
May 11, 2021·Mikrochimica Acta·Li ZhangXiaojuan Gong
May 28, 2021·Research : a Science Partner Journal·Xiulin YiFu-Gen Wu
Feb 6, 2020·The Journal of Physical Chemistry Letters·Wen SuLouzhen Fan
Jun 2, 2020·ACS Omega·Binesh UnnikrishnanHuan-Tsung Chang
Nov 4, 2021·ACS Applied Materials & Interfaces·Shaojing ZhaoWenjun Zhang
Nov 17, 2021·ACS Applied Materials & Interfaces·Pengli GaoMin Zheng

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