Nucleophilic amination of methoxypyridines by a sodium hydride-iodide composite

Chemical Communications : Chem Comm
Jia Hao PangShunsuke Chiba

Abstract

A new protocol for nucleophilic amination of methoxypyridines and their derivatives was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI). The method offers a concise access to various aminopyridines which are potentially of medicinal interest.

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Citations

Feb 27, 2019·Chemistry : a European Journal·Masanori ShigenoYoshinori Kondo
Apr 17, 2019·Angewandte Chemie·Simon RohrbachJohn A Murphy
Jun 24, 2020·Chemical Communications : Chem Comm·Kanako Nozawa-KumadaYoshinori Kondo
Jan 21, 2021·The Journal of Organic Chemistry·Ryan A Woltornist, David B Collum
Aug 29, 2020·Chemical Reviews·Zihang Qiu, Chao-Jun Li
Nov 12, 2020·Organic Letters·Masanori ShigenoYoshinori Kondo
Jul 3, 2019·Organic Letters·Masanori ShigenoYoshinori Kondo
Jun 3, 2020·Organic Letters·Nicholas J Venditto, David A Nicewicz

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Methods Mentioned

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