Nucleophilic selectivity of carcinogens as a determinant of enhanced mutational response in excision repair-defective strains in Drosophila: effects of 30 carcinogens

Carcinogenesis
E W Vogel

Abstract

Consequences on mutation induction of a defective excision repair (exr-) system have been studied in Drosophila for a series of 30 carcinogens, representing 17 mono-, six bi- or trifunctional agents, five cyclic alkylating agents and two polycyclic aromatic compounds. Repair-inactive spermatozoa or (late) spermatids were mutagenized and then transferred to excision-defective (mei-9L1) or appropriate excision proficient (exr+) oocytes. Hypermutability responses in exr- in relation to the exr+ genotype were determined by calculating frep-/frep- (ratio = y) indices at x = 1% X-linked recessive lethal mutations (SLRL); frep- denotes induced SLRL frequency in mei-9L1, frep+ that induced in repair-proficient condition, and x = 1 means 1% SLRL in exr+, A linear positive relationship between frep-/frep+ estimates and nucleophilic selectivity (Swain and Scott's constants s) was established for 18 carcinogens, representing either mono- and cyclic alkylating agents: frep-/frep+ = 12.4s - 1.9; r = 0.79, r2 = 0.62, P less than 0.01 Noticeable exceptions to this linear correlation indicated that, although nucleophilicity is a principle determinator for hypermutability response in exr- mutants, other cellular factors play a significant role a...Continue Reading

Citations

Aug 1, 1995·Mutation Research·E W Vogel, A T Natarajan
Jun 12, 1996·Mutation Research·C RamelS Consuegra
Jun 1, 1995·Mutation Research·J K Wiencke, J Wiemels
Sep 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Apr 22, 1993·Environmental Health Perspectives·J AshbyI Kimber
Oct 1, 1993·Environmental Health Perspectives·F H Sobels
Jan 1, 1993·Environmental and Molecular Mutagenesis·E W VogelM J Nivard
Apr 30, 2003·Environmental and Molecular Mutagenesis·L AlvarezL M Sierra
Oct 12, 2010·Journal of Nucleic Acids·Nancy Díaz-ValdésL María Sierra

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