Nucleoside analogues for the treatment of coronavirus infections

Current Opinion in Virology
Andrea J Pruijssers, Mark R Denison


Recent outbreaks of SARS-Coronavirus and MERS-Coronavirus (CoV) have heightened awareness about the lack of vaccines or antiviral compounds approved for prevention or treatment of human or potential zoonotic CoVs. Anti-CoV drug development has long been challenged by the activity of a 3' to 5' proofreading exoribonuclease unique to CoVs. Recently, a promising nucleoside analogue with broad-spectrum activity against CoVs has been identified. This review will discuss progress made in the development of antiviral nucleoside and nucleotide analogues targeting viral RNA synthesis as effective therapeutics against CoV infections and propose promising strategies for combination therapy.

Associated Clinical Trials


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Jan 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Leonardo LupacchiniPatrizia Russo
Feb 16, 2021·Research in Veterinary Science·Giacomo RossiSara Mangiaterra
Aug 28, 2020·Molecular Cell·Fran RobsonWai-Lung Ng
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Nov 10, 2020·Journal of Virological Methods·Cecilia EydouxJean-Claude Guillemot
Apr 16, 2021·ACS Pharmacology & Translational Science·Ting ChenCarmay Lim
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