Nucleoside deaminase: an enzymatic marker for stress erythropoiesis in the mouse

The Journal of Clinical Investigation
I K RothmanR Silber


The level of nucleoside deaminase was determined in extracts of mouse tissues obtained during a period of accelerated erythropoiesis induced by hypoxia, hemorrhage, or the injection of phenylhydrazine. Under these conditions a striking (10- to 100-fold) elevation of the enzyme activity occurred in the spleen. Similar results were obtained with the injection of purified erythropoietin. In control animals, only a trace of nucleoside deaminase activity was detected in the blood. During the reticulocyte response which followed erythropoietic stimulation, there was a sharp increase in the blood level of nucleoside deaminase, which rose up to 120 times that of control animals. By differential centrifugation, the enzyme was localized to the reticulocyte-rich fraction. Erythrocyte nucleoside deaminase remained elevated even after the reticulocyte count had fallen to normal in the phenylhydrazine-treated mice or to zero after the cessation of hypoxia. There was a very gradual decline in the enzyme activity in the blood which fell to the barely detectable control levels about 45 days after the initial reticulocyte response, a time period which corresponds to the survival of the mouse red blood cell. The persistence of high levels of nucl...Continue Reading


Apr 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·C Van Gastel, C Bishop
Oct 1, 1965·The Journal of Clinical Investigation·R S Hillman, E R Giblett
Mar 29, 1968·Annals of the New York Academy of Sciences·D OrlicJ A Rhodin
Jan 1, 1968·Biologia Neonatorum. Neo-natal Studies·V A ScribnerJ LOBUE
Apr 1, 1968·The Journal of Clinical Investigation·S PiomelliE L Amorosi
May 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·R ShadduckF STOHLMAN
Jan 1, 1969·European Journal of Biochemistry·G B Wisdom, B A Orsi
Mar 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·L N CantorA S GORDON
Jul 1, 1969·The Journal of Clinical Investigation·E R Burka
Jan 1, 1969·British Journal of Haematology·A GanzoniC A Finch
Apr 1, 1969·British Journal of Haematology·I R HannaL F Lamerton
Sep 1, 1969·The Journal of Clinical Investigation·E R Burka
Dec 1, 1965·Journal of Ultrastructure Research·D OrlicJ A Rhodin
Mar 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·G M BrittinG BRECHER
Jan 4, 1966·Biochimica Et Biophysica Acta·H WALTER, F W Selby
Jul 1, 1955·British Journal of Haematology·A C ALLISON, G P BURN
Mar 1, 1956·Canadian Journal of Biochemistry and Physiology·D RUBINSTEINO F DENSTEDT
May 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·L H SMITH, J TOHA
Sep 1, 1959·The Journal of Clinical Investigation·R E BERNSTEIN
Aug 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·G BRECHER, F STOHLMAN
Aug 16, 1962·The New England Journal of Medicine·F STOHLMAN
Aug 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·F STOHLMAN
Apr 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·J LOBUEH QUASTLER
Jul 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·J A GRASSOH SWIFT
Aug 17, 1963·Nature·G J BREWER, R D POWELL
Nov 1, 1963·Canadian Journal of Biochemistry and Physiology·M D SASSH WALTER
Dec 1, 1963·The Journal of Clinical Investigation·J R BERTINOF M HUENNEKENS
Dec 1, 1951·Proceedings of the Society for Experimental Biology and Medicine·N I BERLIN, C LOTZ


Jan 1, 1978·Biulleten' eksperimental'noĭ biologii i meditsiny·S Ia Davydova, S S Vetchinin
May 1, 1976·Metabolism: Clinical and Experimental·I H FoxS Lacroix
Dec 15, 1983·The New England Journal of Medicine·B E GladerL K Diamond
Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G H Reem, C Friend
Aug 27, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Wen GuoShalender Bhasin
Oct 1, 1972·Journal of Cellular Physiology·R S BaschR Silber

Related Concepts

Friend Murine Leukemia Virus
Cavia porcellus
Hematocrit Procedure

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.