PMID: 8972862Dec 1, 1996Paper

Nucleosome assembly on the human c-fos promoter interferes with transcription factor binding

Nucleic Acids Research
C Schild-PoulterM Schnarr

Abstract

cAMP-responsive-element (CRE)-binding factors interaction with nucleosomal DNA has been investigated in vitro on the human c-fos promoter. Analysis of nucleosome reconstitution of this promoter shows a preferential nucleosome positioning on the proximal promoter sequences, including the CRE centered at -60 relative to the start site of transcription. CRE-binding protein (CREB) and modulator protein (CREM) are unable to interact with their recognition site incorporated in a nucleosome. However, competition between transcription factor binding and nucleosome assembly allows CREM binding and induces important modifications in the nucleosomal structure suggesting the displacement of nucleosomes. These findings imply that binding of transcription factors to the CRE prior to cAMP induction might be required to prevent the incorporation of this element in a nucleosome.

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Citations

Oct 13, 2005·Biochemical and Biophysical Research Communications·Xuefang PanXianlu Zeng
Aug 10, 2010·Genomics, Proteomics & Bioinformatics·Kaifu ChenJun Yu
Aug 9, 2007·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Lucie CluverDon Operario
Jan 9, 1999·The Journal of Biological Chemistry·M C MottaR Mantovani
Mar 19, 1999·Molecular and Cellular Biology·D J MurphyD A Engel
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Klaus TenbrockGeorge C Tsokos
Jun 30, 2007·The Journal of Biological Chemistry·Min ZhangB Paul Herring
Jun 26, 1998·Journal of Molecular Biology·J BoyesG Felsenfeld
Nov 7, 1998·Biochimica Et Biophysica Acta·R Adroer, R Oliva

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