PMID: 9420326Feb 21, 1998Paper

Nucleosome positioning by the winged helix transcription factor HNF3

Genes & Development
E Y ShimK S Zaret

Abstract

Nucleosome positioning at genetic regulatory sequences is not well understood. The transcriptional enhancer of the mouse serum albumin gene is active in liver, where regulatory factors occupy their target sites on three nucleosome-like particles designated N1, N2, and N3. The winged helix transcription factor HNF3 binds to two sites near the center of the N1 particle. We created dinucleosome templates using the albumin enhancer sequence and found that site-specific binding of HNF3 protein resulted in nucleosome positioning in vitro similar to that seen in liver nuclei. Thus, binding of a transcription factor can position an underlying nucleosome core.

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Citations

Sep 26, 2002·Developmental Biology·Peter Carlsson, Margit Mahlapuu
Aug 30, 2008·Transgenic Research·F Martín-de-LaraJ Rey-Campos
Oct 31, 1998·Current Opinion in Genetics & Development·K Zaret
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·D Q ShihM Stoffel
Jan 1, 2000·Journal of Biomolecular Structure & Dynamics·M FojtaE Palecek
Mar 4, 2000·The EMBO Journal·S BelikovO Wrange
Feb 21, 2004·Nucleic Acids Research·Li ChenErik Bateman
Nov 8, 2011·Genes & Development·Kenneth S Zaret, Jason S Carroll
Oct 16, 2004·Molecular and Cellular Biology·Lingyun Long, Brett T Spear
May 15, 2013·PloS One·Steven E WeickselCharles G Sagerström
Sep 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·D K PeytonB T Spear
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·David Q ShihMarkus Stoffel
Jun 17, 2009·Developmental Biology·Marta Radman-Livaja, Oliver J Rando
Jan 11, 2002·Developmental Biology·S D Marshall, J D McGhee
Dec 20, 2002·Mechanisms of Development·Stephen A Duncan
Dec 12, 2002·Diabetes·Danielle MelloulErol Cerasi
Sep 1, 2000·Journal of Molecular Biology·C Pérez-SánchezJ Rey-Campos
Sep 29, 2009·Differentiation; Research in Biological Diversity·Josée SavageIlona S Skerjanc

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