Nucleotide and amino acid sequences of the metallo-beta-lactamase, ImiS, from Aeromonas veronii bv. sobria.

Antimicrobial Agents and Chemotherapy
T R WalshP M Bennett

Abstract

The Aeromonas veronii bv. sobria metallo-beta-lactamase gene, imiS, was cloned. The imiS open reading frame extends for 762 bp and encodes a protein of 254 amino acids with a secreted modified protein of 227 amino acids and a predicted pI of 8.1. To confirm the predicted sequence, purified ImiS was digested and the resulting peptides were identified, yielding an identical sequence for ImiS, with 98% identity to CphA. Both possessed the putative active-site sequence Asn-Tyr-His-Thr-Asp at positions 88 to 92, which is unique to the Aeromonas metallo-beta-lactamases.

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Citations

Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Tanya A MurphyTimothy R Walsh
May 15, 2001·The Journal of Biological Chemistry·M B AvisonP M Bennett
Aug 25, 2015·FEBS Letters·María-Rocío MeiniAlejandro J Vila
Jan 9, 2016·Japanese Journal of Infectious Diseases·Mika MurataKatsunori Yanagihara
Apr 16, 2005·Clinical Microbiology Reviews·Timothy R WalshPatrice Nordmann
Jun 17, 2020·Antimicrobial Agents and Chemotherapy·Paola Sandra MercuriMoreno Galleni
Oct 6, 1999·Current Opinion in Chemical Biology·Z WangS J Benkovic
Mar 30, 2006·Antimicrobial Agents and Chemotherapy·George A Jacoby
Feb 22, 2001·Antimicrobial Agents and Chemotherapy·M GalleniUNKNOWN Metallo-beta-lactamases Working Group
Oct 22, 2003·Pathologie-biologie·T FosseI Madinier
Aug 1, 2002·Journal of Clinical Microbiology·Timothy R WalshAna Gales
May 26, 2004·Analytical Biochemistry·Ke-Wu Yang, Michael W Crowder
Jul 14, 2004·Protein Expression and Purification·Patrick A CrawfordMichael W Crowder

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