DOI: 10.1101/501130Dec 19, 2018Paper

Nucleotide Archival Format (NAF) enables efficient lossless reference-free compression of DNA sequences

BioRxiv : the Preprint Server for Biology
Kirill KryukovTadashi Imanishi


Summary: DNA sequence databases use compression such as gzip to reduce the required storage space and network transmission time. We describe Nucleotide Archival Format (NAF) - a new file format for lossless reference-free compression of FASTA and FASTQ-formatted nucleotide sequences. NAF compression ratio is comparable to the best DNA compressors, while providing dramatically faster decompression. We compared our format with DNA compressors: DELIMINATE and MFCompress, and with general purpose compressors: gzip, bzip2, xz, brotli, and zstd. Availability and implementation: NAF compressor and decompressor, as well as format specification are available at Format specification is in public domain. Compressor and decompressor are open source under the zlib/libpng license, free for nearly any use. Contact:

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