PMID: 3384017May 1, 1988Paper

Nucleotide binding to the rod outer segment rim protein

Experimental Eye Research
T A ShusterD B Farber

Abstract

The rod photoreceptor outer segment maintains a remarkable morphology. Two of the proteins which have been implicated in the maintenance of this structure are the 240 kDa spectrin-like protein, and the 220 kDa glycoprotein often referred to as the rim protein. We have probed rat rod outer segment proteins with light-activated (azido-labeled) radioactive nucleotides and found a nucleotide binding site(s) on the rim protein which has a preference for guanine nucleotides. Binding to this site is stimulated by the divalent cations zinc, manganese and magnesium, but not calcium. This site is under investigation and may play a role in stabilizing protein structure.

References

Sep 1, 1976·Nucleic Acids Research·I L CartwrightV W Armstrong
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Sep 7, 1976·Biochemical and Biophysical Research Communications·S W TamF W Wagner
Jan 1, 1986·Annual Review of Neuroscience·L Stryer
Apr 1, 1988·Experimental Eye Research·T A ShusterD B Farber
Sep 23, 1986·Biochemistry·G HegyiM Elzinga
Oct 7, 1986·Biochemistry·S Wong, R S Molday
Dec 15, 1974·FEBS Letters·C GoridisM A Delaage
Mar 28, 1972·Biochemistry·S S Lehrer, G Kerwar
Jan 31, 1984·Biochemistry·T A Shuster, D B Farber
Nov 1, 1982·The Journal of Cell Biology·D J Roof, J E Heuser
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B Kwok-Keung Fung, L Stryer
Jan 1, 1982·Methods in Enzymology·H G Smith, B J Litman

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Citations

Dec 1, 1990·Visual Neuroscience·A Sitaramayya, S Hakki
Aug 29, 2013·Biochemistry. Biokhimii︠a︡·S A Shukolyukov
Apr 1, 1988·Experimental Eye Research·T A ShusterD B Farber
Apr 11, 1997·The Journal of Biological Chemistry·M IllingR S Molday

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