Nucleotide polymorphism in colicin E2 gene clusters: evidence for nonneutral evolution

Molecular Biology and Evolution
Y Tan, M A Riley

Abstract

To explore the molecular mechanisms behind the diversification of colicin gene clusters, we examined DNA sequence polymorphism for the colicin gene clusters of 14 colicin E2 (ColE2) plasmids obtained from natural isolates of Escherichia coli. Two types of ColE2 plasmids are revealed, with type II gene clusters generated by recombination between type I ColE2 and ColE7 gene clusters. The levels and patterns of DNA polymorphism are different between the two types. Type I polymorphism is distributed evenly along the gene cluster, while type II accumulates polymorphism at an elevated rate in the 5' end of the colicin gene. These differences may be explained by recombinational origins of type II gene clusters. The pattern of divergence between the ColE2 gene cluster and its close relative ColE9 is not correlated with the pattern of polymorphism within ColE2, suggesting that this gene cluster is not evolving in a neutral fashion. A statistical test confirms significant departures from the predictions of neutrality. These data lend further support to the hypothesis that colicin gene clusters may evolve under the influence of nonneutral forces.

Citations

May 11, 2005·Journal of Molecular Evolution·Milind ChavanMargaret A Riley
Nov 9, 2002·Biochimie·Margaret A Riley, John E Wertz
Feb 20, 1998·Current Opinion in Genetics & Development·C F Aquadro
Oct 9, 2001·Trends in Biochemical Sciences·C Kleanthous, D Walker
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·M A RileyJ Wang
May 7, 2003·Applied and Environmental Microbiology·Trine NilsenHelge Holo
Mar 5, 2004·Journal of Bacteriology·John E Wertz, Margaret A Riley
Mar 10, 2007·Microbiology and Molecular Biology Reviews : MMBR·Eric CascalesDanièle Cavard
Feb 3, 1999·Annual Review of Genetics·M A Riley
Nov 28, 2007·Evolution; International Journal of Organic Evolution·Federico Prado, Benjamin Kerr
Sep 6, 2001·Plasmid·T Pinou, M A Riley
Jul 27, 2002·Annual Review of Microbiology·Margaret A Riley, John E Wertz
Mar 24, 2004·Journal of Food Protection·Gerry P Schamberger, Francisco Diez-Gonzalez
Dec 1, 2004·EcoSal Plus·Margaret A RileyCarla Goldstone
Jun 25, 2015·Microbiology Spectrum·María de ToroFernando De La Cruz

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