PMID: 11913778Mar 27, 2002Paper

Nucleotide sequence analysis of a transforming gene isolated from nasopharyngeal carcinoma cell line CNE2: an aberrant human immunoglobulin kappa light chain which lacks variable region

DNA Sequence : the Journal of DNA Sequencing and Mapping
M LiYa Cao

Abstract

A transforming gene, designated Tx, was isolated from a human nasopharyngeal carcinoma (NPC) cell line CNE2 by transfection and molecular cloning techniques. The Tx gene was analyzed using computer-based bioinformatics and compared with the known sequences in EMBL and GenBank databases. We found that Tx contains human immunoglobulin kappa light chain constant region, five intact joining regions J1-J5, five recombination signal sequences and an N-segment besides classic regulatory sequences such as TATA boxes, CAAT boxes, poly A signals, etc. Interestingly, Tx also contains several binding sites for nuclear transcription factors such as NF-kappaB, NF-IL6, TFIID, etc. In conclusion, there are only several base pairs mutations or deletions compared with normal Ig K JC gDNA fragment. In all, Tx is an aberrant human immunoglobulin kappa light chain that contains the constant region, five joining regions, which lacks the variable regions.

Citations

Aug 18, 2004·The International Journal of Biochemistry & Cell Biology·Ming LiYa Cao
Jun 10, 2004·Genes, Chromosomes & Cancer·Zhongxi HuangKaitai Yao
Aug 24, 2011·Cellular & Molecular Immunology·Duosha HuYa Cao
Apr 30, 2003·World Journal of Gastroenterology : WJG·Jian-Bin HuYong-Chuan Deng

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