PMID: 19912808Jun 1, 1991Paper

Nucleotide sequence and expression of the mouse corticotropin-releasing hormone gene

Molecular and Cellular Neurosciences
A F SeasholtzS A Camper

Abstract

The mouse corticotropin-releasing hormone (CRH) gene has been isolated and characterized by DNA sequence analysis. The gene exhibits a structural organization similar to that of the human, rat, and ovine genes with two exons and an intervening sequence of 675 base pairs interrupting the 5' untranslated sequence of the mature mRNA. Analysis of the nucleotide sequence reveals that the mouse CRH peptide is identical at the amino acid level to the human and rat CRH peptides, with only three nucleotide changes between the rat and mouse sequences within the CRH peptide-encoding region. Additionally, the mouse CRH gene exhibits greater than 92% homology to the rat, human, and ovine CRH genes within the first 336 nucleotides of 5' flanking DNA, suggesting that this sequence contains important transcriptional control elements which have been conserved across species to mediate the regulation of this important neuroendocrine peptide. The expression of the mouse CRH gene in brain is demonstrated using in situ hybridization analysis. Mouse CRH mRNA can be detected in the paraventricular nucleus of the hypothalamus and inferior olivary nucleus of mouse brain.

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Citations

Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L T KnappS A Camper
Jun 1, 1995·Molecular and Cellular Endocrinology·D N CortrightA F Seasholtz
Jun 19, 2013·Journal of Chemical Neuroanatomy·Krisztina J Kovács
May 5, 2001·Peptides·M PisarskaJ W Kasckow
Dec 29, 1995·Annals of the New York Academy of Sciences·J A MajzoubL Jacobson
Mar 22, 1996·Annals of the New York Academy of Sciences·L MugliaJ A Majzoub
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·I J KarolyiA F Seasholtz
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S C WeningerJ A Majzoub
Aug 5, 2003·The Journal of Clinical Investigation·Daniela CotaUberto Pagotto
Jan 21, 2000·Mechanisms of Development·J L MichaudC M Fan
Jun 22, 1999·General and Comparative Endocrinology·D A Lovejoy, R J Balment
Jun 28, 2002·Diabetes·Rexford S AhimaMichael A Zasloff
Jul 5, 2016·Alcoholism, Clinical and Experimental Research·Kyle D KetchesinAudrey F Seasholtz
Aug 16, 2018·Physiological Reviews·Jan M Deussing, Alon Chen
Sep 16, 2017·Journal of Molecular Endocrinology·Yuxiao TangMin Li
Jul 31, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marianne B MüllerManfred Uhr
Feb 28, 2004·Molecular Endocrinology·Eleni GoshuChen-Ming Fan
Aug 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A SlominskiE T Wei
May 25, 2002·Molecular and Cellular Biology·Eleni GoshuChen-Ming Fan
Sep 25, 2004·Endocrinology·Kristien VandenborneSerge Van der Geyten
Nov 8, 2005·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Keiichi Itoi
Jun 13, 2003·Life Sciences·J W KasckowJ P Herman

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