PMID: 8948378Dec 1, 1996Paper

Nucleotide sequence and restriction fragment-length polymorphism analysis of human T-cell lymphotropic virus type II (HTLV-II) in southern Europe: evidence for the HTLV-IIa and HTLV-IIb subtypes

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
A VallejoI K Hewlett

Abstract

Human T-cell lymphotropic virus type II (HTLV-II) has been subtyped into two major groups, IIa and IIb, according to molecular studies involving env gene sequencing. Subsequently, this retrovirus was further subclassified by examining the long terminal repeat (LTR), the most divergent genomic region. Sequence analysis and restriction fragment-length polymorphism (RFLP) applied to the LTR region identified either four or five groups within the IIa subtype (depending on the restriction enzyme sets used) and six within the IIb subtype. In this study, we analyzed the LTR sequences of 29 samples obtained from HTLV-II-infected individuals living in Spain and Italy, which included 24 injecting drug users (IDUs), three blood donors, and two subjects at risk for HIV/HTLV infection. Sequence analysis and phylogenetic analysis of 720 base pairs of the LTR performed in 10 Spanish samples showed that all of these samples belonged to IIb subtype, with a divergence of 7.5% and 1.66% compared with MoT (IIa) and NRA/G12 (IIb) isolates, respectively. RFLP analysis demonstrated the presence of the IIb 4-subtype restriction pattern in 26 samples, a IIb5-subtype pattern in one Italian IDU, and a IIa0-subtype pattern in two Italian samples (blood do...Continue Reading

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Citations

Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·M SalemiA M Vandamme
Jan 1, 1994·Vox Sanguinis·A Vallejo, A García-Sáiz
Jan 10, 2002·Journal of Medical Virology·Edimilson A SilvaAna Carolina P Vicente
Mar 31, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Carlos ToroUNKNOWN HTLV Spanish Study Group
Feb 16, 2020·Retrovirology·Ricardo IshakAntonio Carlos R Vallinoto
Oct 8, 1997·Journal of Clinical Microbiology·S Zou

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