PMID: 870828Feb 24, 1977

Nucleotide sequence of bacteriophage phi X174 DNA

Nature
F SangerM Smith

Abstract

A DNA sequence for the genome of bacteriophage phi X174 of approximately 5,375 nucleotides has been determined using the rapid and simple 'plus and minus' method. The sequence identifies many of the features responsible for the production of the proteins of the nine known genes of the organism, including initiation and termination sites for the proteins and RNAs. Two pairs of genes are coded by the same region of DNA using different reading frames.

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Related Concepts

Viral Proteins
Transcription, Genetic
DNA, Viral
Transcription Initiation
Sense Codon
Genes, Regulator
Ribosomes
Reading Frames (Nucleotide Sequence)
Nucleotides
Organism

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