Nucleotide sequence of htpB, the Legionella pneumophila gene encoding the 58-kilodalton (kDa) common antigen, formerly designated the 60-kDa common antigen.

Infection and Immunity
J S SampsonL W Mayer

Abstract

Gene htpB, which encodes the 58-kilodalton protein of Legionella pneumophila, was cloned in Escherichia coli and its complete nucleotide sequence was determined. Analysis of this sequence revealed an open reading frame of 1,644 nucleotides encoding a protein with a predicted molecular mass of 57,952 daltons. Data obtained by amino-terminal sequencing of the purified 58-kilodalton protein agreed, except for one amino acid residue, with the predicted amino acid sequence, identifying this open reading frame as htpB. A comparison of the primary structure of this protein to other proteins of similar molecular weights from E. coli, Mycobacterium leprae, M. tuberculosis, and Coxiella burnetii revealed significant regions of sequence similarity, which are discussed.

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Citations

Nov 27, 2002·Applied and Environmental Microbiology·Wakako SatohKeiichi Hiramatsu
Mar 4, 2008·Microbiology·Martin T EdwardsTimothy G Harrison
Jun 1, 1994·FEMS Microbiology Reviews·M Ott
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May 11, 1992·Infection and Immunity·D J EvansD Y Graham
Nov 1, 1991·Journal of Bacteriology·P MazodierC J Thompson

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