PMID: 9187299May 17, 1997Paper

Nucleotide sequence of human alkyl-dihydroxyacetonephosphate synthase cDNA reveals the presence of a peroxisomal targeting signal 2

Biochimica Et Biophysica Acta
E C de VetH van den Bosch

Abstract

Two overlapping clones were isolated from a human liver cDNA library in lambda gt11 that coded for human alkyl-dihydroxyacetonephosphate synthase using guinea pig and PCR-derived human cDNA probes. The open reading frame encodes a protein of 658 amino acids that shows a homology of 92% with the guinea pig homolog and a similarity of 98%. The peroxisomal targeting signal 2 that was recently identified in the presequence of the guinea pig enzyme appeared to be completely preserved in the human enzyme. Supportive confirmation for parts of the sequence of the mature protein was obtained from the Expressed Sequence Tags database of the National Center for Biotechnology Information. This database contained nine cDNA sequences, derived from seven independent clones, that correspond exactly to parts of the cDNA of human alkyl-dihydroxyacetonephosphate synthase. One of these clones most likely represents a not fully processed RNA with a putative intron containing an Alu sequence. An unexpected homology with D-lactate dehydrogenase (cytochrome C) precursor from Saccharomyces cerevisiae and with glycolate oxidase subunit D from Escherichia coli was also revealed.

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Citations

May 29, 2004·Biochimica Et Biophysica Acta·Dennis E Vance, Friedrich Spener
May 29, 2004·Biochimica Et Biophysica Acta·Pedro BritesRonald J A Wanders
Nov 25, 1997·Biochimica Et Biophysica Acta·H van den Bosch, E C de Vet
Oct 31, 1998·Biochimica Et Biophysica Acta·T C Lee
Nov 25, 1998·Molecular Aspects of Medicine·R J Wanders, J M Tager
Dec 10, 1999·Molecular and Biochemical Parasitology·A W ZomerF R Opperdoes
Mar 14, 2003·Biochimica Et Biophysica Acta·Ronald J A WandersMatthew D Lloyd
Dec 4, 2012·International Journal of Molecular Sciences·Pablo Sobrado
Mar 26, 2013·Journal of Proteomics·L M BreckelsM W B Trotter
Aug 31, 2000·Annual Review of Biochemistry·S SubramaniW B Snyder
Jul 23, 1999·Archives of Biochemistry and Biophysics·J Biermann, H van den Bosch
Mar 7, 2009·Biochimica Et Biophysica Acta·Non MiyataYukio Fujiki
Oct 30, 1998·American Journal of Human Genetics·C C Chang, S J Gould
Nov 30, 2014·Journal of Inherited Metabolic Disease·Ana R MalheiroPedro Brites
Aug 16, 2002·Physiological Genomics·Oleh I PetrivVladimir I Titorenko
Feb 29, 2000·The Journal of Biological Chemistry·E C de VetH van den Bosch
Jan 20, 2004·Journal of Cell Science·Sietske HogenboomHans R Waterham
Jul 13, 2000·Journal of Molecular Biology·D M ChudzikW G Hol
Dec 5, 1998·Biochemical and Biophysical Research Communications·E C de Vet, H van den Bosch
Feb 16, 1999·Biochimica Et Biophysica Acta·F Snyder
Aug 18, 2004·Journal of Molecular Biology·Oleh I PetrivRichard A Rachubinski
Oct 7, 2004·Molecular Genetics and Metabolism·R J A Wanders
Jul 3, 2007·Protein Expression and Purification·Adelia RazetoAndrea Mattevi

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