PMID: 3753629Jan 15, 1986Paper

Nucleotide sequence of the Bunyamwera virus M RNA segment: conservation of structural features in the Bunyavirus glycoprotein gene product

Virology
J F LeesR M Elliott

Abstract

The complete nucleotide sequence of the Bunyamwera virus M RNA segment was determined from four overlapping cDNA clones and by primer extension. The RNA segment is 4458 bases in length, and encodes a single gene product in the viral complementary RNA. The predicted protein is 1433 amino acids long (mol wt 162,065), contains four potential glycosylation sites, and is relatively cysteine rich. It is presumed that the three proteins G1, G2, and NSM which have been mapped to the M RNA segment are synthesized as a precursor polyprotein which is subsequently proteolytically cleaved. A putative hydrophobic signal sequence at the amino terminus and a hydrophobic anchor sequence at the carboxy terminus of the predicted protein have been identified, in addition to internal regions of hydrophobicity of unknown function. The nucleotide and amino acid sequences of the Bunyamwera virus M segment have been compared with those of the snowshoe hare virus M segment (Y. Eshita and D. H. L. Bishop, Virology 137, 227-240, 1984). Common features include the overall architecture of the RNAs, single cysteine-rich primary gene products, and conservation of hydrophobic domains in the gene products. When aligned the amino acid sequences are 43% homologou...Continue Reading

References

Oct 10, 1977·Biochemical and Biophysical Research Communications·M H Klapper
May 24, 1980·Nucleic Acids Research·D R Smith, J M Calvo
Jan 1, 1980·Intervirology·D H BishopE G Westaway
Jun 1, 1983·The Journal of General Virology·G Abraham, A K Pattnaik
Jan 11, 1982·Nucleic Acids Research·R M BlumenthalR J Roberts
Aug 11, 1982·Nucleic Acids Research·J Pustell, F C Kafatos
Jan 11, 1984·Nucleic Acids Research·P Taylor
Jul 30, 1983·Virology·C D CabradillaJ F Obijeski
Jun 1, 1983·European Journal of Biochemistry·G von Heijne
Nov 1, 1982·Molecular and Cellular Biology·E KuismanenR F Pettersson
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·G Blobel
Jun 25, 1982·Nucleic Acids Research·D H BishopC M Clerx-van Haaster
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
Oct 24, 1980·Nucleic Acids Research·C M Rubin, C W Schmid

❮ Previous
Next ❯

Citations

Sep 18, 2009·Virus Genes·Stacey L WattsJames E Maruniak
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·N L DavisR E Johnston
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·A Bridgen, R M Elliott
Sep 16, 2004·Journal of Virology·Xiaohong ShiRichard M Elliott
Dec 1, 1988·Virology·J K FazakerleyN Nathanson
Aug 4, 2011·Journal of Invertebrate Pathology·Stefan W Metz, Gorben P Pijlman
Oct 1, 1992·Virology·A C MarriottP A Nuttall
Jul 16, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Lucie DufkovaNorbert Nowotny
Sep 28, 2004·The Journal of General Virology·Thomas BrieseW Ian Lipkin
Apr 19, 2017·Critical Reviews in Microbiology·Abdennour AmrounGilles Quérat
Jul 3, 2009·The Journal of General Virology·Xiaohong ShiRichard M Elliott

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.