Nucleotide sequence of the chromosomal gene for human fibroblast (beta 1) interferon and of the flanking regions

Gene
W DegraveW Fiers

Abstract

The nucleotide sequence of the human fibroblast (beta 1) interferon chromosomal gene and its flanking regions was determined. These results confirm the absence of intervening sequences in the gene. The presence of some sequences in the upstream flanking region homologous to similar features for other eukaryotic genes was revealed: these include not only the TATAAAT sequence and the consensus sequence (reported by Benoist et al., 1980) but also two additional motifs, one of which is so far present only in inducible genes. Furthermore, a striking similarity between the upstream flanking regions of the human beta 1 and alpha 1 interferon genes is observed.

References

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Citations

Jan 1, 1985·Pharmacology & Therapeutics·J A Langer, S Pestka
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P M PithaG S Hayward
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D Canaani, P Berg
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P W Gray, D V Goeddel
Sep 1, 1982·The Journal of Experimental Medicine·A D SagarF H Ruddle
Mar 1, 1983·The Journal of Experimental Medicine·S L NaylorP W Gray
Jan 1, 1982·Journal of Interferon Research·A MeagerJ Vilcek
Aug 1, 1994·Journal of Interferon Research·G Allen, M O Diaz
Feb 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G Allen, M O Diaz
Jun 25, 1982·Nucleic Acids Research·R DerynckD V Goeddel
Feb 11, 1985·Nucleic Acids Research·E C ZwarthoffJ Trapman
Sep 30, 1982·Biochimica Et Biophysica Acta·P B Sehgal
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P VollingH Tesch
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Aug 26, 1982·Nature·P W Gray, D V Goeddel
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W FiersJ Content

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