Nucleotide sequence of the genes encoding the canine herpesvirus gB, gC and gD homologues

The Journal of General Virology
K J LimbachE Paoletti

Abstract

The nucleotide sequence of the genes encoding the canine herpesvirus (CHV) gB, gC and gD homologues was determined. These genes are predicted to encode polypeptides of 879, 459 and 345 amino acids, respectively. Comparison of the predicted amino acid sequences of CHV gB, gC and gD with the homologous sequences from other herpesviruses indicates that CHV is an alphaherpesvirus, a conclusion that is consistent with the previous classification of this virus according to biological properties. Alignment of the homologous gB, gC and gD amino acid sequences indicates that most of the cysteine residues are conserved, suggesting that these glycoproteins possess similar tertiary structures. The nucleotide sequence of the open reading frame downstream from the CHV gC gene was also determined. The predicted amino acid sequence of this putative polypeptide appears to be homologous to a family of proteins encoded downstream from the gC gene in most, although not all, alphaherpesviruses.

Citations

Nov 26, 2003·Antiviral Research·Tetsuya TanakaKei ichi Shimazaki
Jul 24, 2002·Virus Research·Yoshifumi NishikawaHaruki Otsuka
Jun 10, 1998·Virus Research·E J Haanes, C C Tomlinson
Oct 9, 1999·Veterinary Microbiology·K WilloughbyR M Gaskell
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Jan 1, 1997·DNA Sequence : the Journal of DNA Sequencing and Mapping·S G TyackM A Johnson
May 27, 2008·The Veterinary Clinics of North America. Small Animal Practice·Nicola DecaroCanio Buonavoglia
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