PMID: 375227Mar 1, 1979Paper

Nucleotide sequence of the region of an origin of replication of the antibiotic resistance plasmid R6K

Proceedings of the National Academy of Sciences of the United States of America
D M StalkerD R Helinski

Abstract

A 2.1-kilobase segment of the antibiotic resistance plasmid R6K carries sufficient information to replicate as a plasmid in Escherichia coli. This segment contains a functional origin of replication and a structural gene for a protein, designated pi, that is required for the initiation of R6K replication. The nucleotide sequence of a 520-base-pair portion of this 2.1-kilobase segment that includes the functional origin of replication and the region adjacent to the start of the pi structural gene was determined. A striking feature of the sequence is the presence of seven 22-base-pair direct repeats joined in tandem in the region adjacent to the start of the pi gene. A possible role of the tandem repeats in the regulation of expression of the pi protein and the control of initiation of replication of the plasmid R6K is discussed.

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Citations

Oct 1, 1992·Molecular & General Genetics : MGG·M S Okumura, C I Kado
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