PMID: 9170554Jan 1, 1997Paper

Nucleus accumbens dopaminergic mediation of protection against gastric mucosal ulcerations by cold-restraint stress in the male hyperprolactinemic rats

The Chinese Journal of Physiology
J C ShyuC L Chang

Abstract

An investigation was undertaken to study the relationship between change in gastric lesion induced by cold-restraint stress and brain dopamine (DA) activity in male rat with chronic hyperprolactinemia. Male rats of Wistar strain were divided into two groups: one received extra two pieces of anterior pituitary (AP) from its littermates, the other grafted with several pieces of muscle served as control. Experiment I: From the 5th day to 40th day after transplantation, the levels of serum prolactin (PRL) in the AP-grafted group were higher than those of control (p < 0.05 or p < 0.01). Experiment II: On the 40th day after transplantation, AP-grafted and control rats were restrained and placed supine in a ventilated refrigerator with an ambient temperature of 5 degrees C for 3 hrs. Although gastric mucosal ulceration was observed in both groups, the ulcer index (including total number and length of gastric mucosal ulceration) was lower in AP-grafted group than that in control group (p < 0.05 or p < 0.01). Experiment III: On the 40th day after transplantation, all rats were divided into AP-grafted and muscle-grafted rats. Subsequently, they were allowed to expose to cold-plus-restraint stress and unstress (room temperature: 24 +/- 1 ...Continue Reading

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.