Abstract
Postictal movement dysfunction is a common symptom in patients with epilepsy. We investigated the involvement of opioid receptors in the nucleus accumbens (NAC) in amygdaloid kindling-induced postictal decrease in locomotion (PDL) in rats. Seizures were induced by daily electrical stimulation of the basolateral amygdala until four consecutive stage 5 seizures were elicited. Locomotion was quantified before and after infusion of an opioid receptor antagonist or saline into the NAC. Whereas PDL was induced after a stage 5 seizure in saline-infused rats, pre-infusion of the mu opioid receptor antagonist H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH(2) (CTAP, 5 microg/1 microL/side) into the NAC prevented PDL. Pre-infusion of delta (naltrindole, 30 microg/1 microL/side), kappa (nor-binaltorphimine, 1.8 microg/1 microL/side), or nonselective (naloxone, 10 microg/1 microL/side) opioid receptor antagonists did not block PDL, but late postictal hyperactivity was blocked by naltrindole. None of the antagonists affected amygdaloid evoked afterdischarge duration. It is suggested that mu opioid receptors in the NAC participate in amygdaloid seizure-induced PDL without affecting seizure duration.
References
Aug 14, 1992·Brain Research·S T Cunningham, A E Kelley
Jan 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·L A RolakY Harati
Sep 1, 1991·Annals of Neurology·M D PriviteraF Gilliam
Feb 12, 1986·Brain Research·M J IadarolaH Y Yang
Jul 15, 1986·The Journal of Comparative Neurology·J H Fallon, F M Leslie
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 1, 1986·Journal of Neuroscience Research·J R NaranjoE Costa
Feb 4, 1985·Brain Research·C L Ehlers, G F Koob
May 23, 1984·Brain Research·N AroninJ Y Wu
Feb 15, 1980·The Journal of Comparative Neurology·V M PickelD J Reis
Jan 1, 1981·Neuroscience Letters·O VindrolaA Fernández-Guardiola
Apr 1, 1994·Progress in Neurobiology·C M PennartzF H Lopes da Silva
Dec 1, 1995·Synapse·R M Beckstead
Nov 11, 1996·Brain Research·J MaL W Leung
Jan 21, 2000·Epilepsy Research·R G ParedesV Romero
May 24, 2003·Neuroscience·S J French, S Totterdell
Jun 24, 2004·Neurology·P GallmetzerC Baumgartner
Jun 15, 2007·Synapse·José Antonio FuentealbaMaría Estela Andrés
Mar 13, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Diana Simmons, David W Self
Jun 6, 2009·Epilepsia·Jennifer J LongL Stan Leung
Citations
Jun 3, 2014·BMC Neurology·Syu-Jyun PengYue-Loong Hsin
Jun 9, 2016·Brain Stimulation·Jingyi Ma, L Stan Leung
Aug 10, 2010·Epilepsy & Behavior : E&B·Jan Rémi, Soheyl Noachtar
Dec 22, 2017·Human Brain Mapping·Xixi ZhaoYikai Xu