PMID: 7370763Apr 21, 1980Paper

Nucleus accumbens to globus pallidus GABA projection: electrophysiological and iontophoretic investigations

Brain Research
D L Jones, G J Mogenson

Abstract

Extracellular recordings were obtained from neurons in the nucleus accumbens and globus pallidus of urethane anesthetized rats. Eight neurons in the nucleus accumbens were activated antidromically following stimulation of the globus pallidus. Calculated conduction velocities were 0.4-1.5 m/sec, indicative of small unmyelinated fibers. A total of 74 of 153 neurons in the globus pallidus responded to stimulation of the nucleus accumbens. Of these neurons 4 (2.7%) were excited only, 46 (30.1%) were inhibited only and 24 (15.7%) had sequential effects to excitation and inhibition. Iontophoretic application of picrotoxin was found to attenuate or abolish the poststimulus inhibition in one-half of the neurons examined. The 74 neurons which responded to stimulation of the nucleus accumbens had slower firing frequencies and generally more random firing patterns than neurons which did not respond to stimulation. Fifty-three per cent of all globus pallidus neurons examined had increased spontaneous firing frequencies following the iontophoretic administration of picrotoxin alone. This is indicative of the removal of a tonic GABA input onto these neurons. Most neurons examined had decreased spontaneous firing frequencies following the ion...Continue Reading

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Citations

Dec 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·P SlaterS L Dickinson
Jan 1, 1993·Journal of Neural Transmission. General Section·J J Chrobak, T C Napier
Jan 1, 1994·Journal of Neural Transmission. General Section·S E Smith, T Sharp
Jun 1, 1994·Psychopharmacology·M R Zarrindast, H Farahvash
Apr 12, 2008·Purinergic Signalling·Ute KrügelHolger Kittner
Apr 1, 1991·Electroencephalography and Clinical Neurophysiology·M SabatinoV La Grutta
Aug 1, 1983·Pharmacology, Biochemistry, and Behavior·K OssowskaS Wolfarth
Jul 1, 1986·Pharmacology, Biochemistry, and Behavior·N R SwerdlowG F Koob
Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·L S WongD M Jackson
Feb 1, 1991·Pharmacology, Biochemistry, and Behavior·P E Shreve, N J Uretsky
Jan 1, 1994·Pharmacology & Therapeutics·D M Jackson, A Westlind-Danielsson
Mar 1, 1986·Brain Research·E Garcia-Rill
Jan 1, 1984·Peptides·J F DeFranceR B Chronister
Dec 4, 1985·Neuroscience Letters·S L Hartgraves, P H Kelly
Sep 1, 1995·General Pharmacology·M R Zarrindast, M Sharifzadeh

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