Nucleus-targeted DNA tetrahedron as a nanocarrier of metal complexes for enhanced glioma therapy

Chemical Communications : Chem Comm
Yiqiao TianTianfeng Chen

Abstract

A negatively-charged and nucleus-targeted DNA tetrahedron is rationally designed and used as a nanocarrier of positively-charged metal complexes. This tetrahedron speeds up the translocation of metal complexes into the cell nucleus, and inhibits the growth and invasion of glioma cells by triggering vascular mimicry-associated signaling pathways, thus achieving precise glioma treatment.

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Citations

Dec 1, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Yuanyuan YouTianfeng Chen
Mar 8, 2019·Advanced Healthcare Materials·Divita Mathur, Igor L Medintz
Feb 21, 2019·Small·Yee Ting Elaine ChiuChung Hang Jonathan Choi
Mar 17, 2020·Future Medicinal Chemistry·Wei TianHuaxin Hou
Jun 27, 2020·Cancer Science·Ratchanee DuangratThaned Kangsamaksin
Feb 8, 2020·Topics in Current Chemistry·Xiaoyi FuXiao-Bing Zhang
Jun 23, 2021·Chemical Reviews·Abhichart KrissanaprasitThomas H LaBean
Oct 2, 2021·Chemical Communications : Chem Comm·Yinghui FengXiaoqing Chen
Oct 9, 2021·Signal Transduction and Targeted Therapy·Wenjuan MaYunfeng Lin

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Methods Mentioned

BETA
nuclear translocation
AFM
Fluorescence
fluorescence spectroscopy
flow cytometry
fluorescence imaging

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