Nucleus transfer in mammals: how the oocyte cytoplasm modifies the transferred nucleus

Theriogenology
J FulkaJosef Fulka

Abstract

Successful development of clones depends on the reprogramming of transferred nuclei in enucleated oocytes. Thus far, oocytes are the only cells that can convert nuclei, which are already differentiated, into undifferentiated stages resembling pronuclei in freshly fertilized zygotes and that can then complete development of the reconstructed embryos. However, we still don't know exactly how the enucleated oocyte (cytoplast) secures this reprogramming. Oocytes exhibit a number of cytoplasmic activities that may be involved reprogramming. We discuss how these activities may be involved in reprogramming of transferred nuclei.

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Citations

Mar 14, 2007·Animal Reproduction Science·Xiao-Yu YangYi-Tao Zeng
Jul 9, 2003·American Journal of Reproductive Immunology : AJRI·J L EdwardsC J Davies
Aug 6, 2018·Journal of Cellular Physiology·Chunling LiQiang Wang

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